133718-30-6
133718-30-6 structure
- Name: R 80123
- Chemical Name: R 80123
- CAS Number: 133718-30-6
- Molecular Formula: C26H29N5O3
- Molecular Weight: 459.540
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2018-02-02 20:23:16
- Modify Date: 2024-01-10 16:37:11
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R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone).In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [3]
| Name | R 80123 |
|---|---|
| Synonyms |
N-Cyclohexyl-N-methyl-2-({(Z)-[(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)(phenyl)methylene]amino}oxy)acetamide
Acetamide, N-cyclohexyl-N-methyl-2-[[[(1Z)-phenyl(1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolin-7-yl)methylene]amino]oxy]- |
| Description | R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. The fuction is similar to R 80122 (HY-100615, Revizinone).In vivo: The administration of Revizinone improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. [1] With regard to reconstitution of contractility and cardiac function Revizinone (E-isomer) is 10 fold more potent than R 79595 and nearly 100 fold more potent than R 80123 (Z-isomer). [2] Revizinone significantly increases global LV function and systolic wall thickening in ischemic areas at doses greater than or equal to 0.16 mg/kg i.v. [3] |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H29N5O3 |
| Molecular Weight | 459.540 |
| Exact Mass | 459.227051 |
| LogP | 3.22 |
| Index of Refraction | 1.677 |
| Storage condition | 2-8℃ |