瑞维齐农

• 常用名: 瑞维齐农
• 英文名: Revizinone
• CAS号: 133718-29-3
• 分子量: 459.54000
• 密度: 1.336g/cm3
• 沸点: 627.743ºC at 760 mmHg
• 分子式: C₂₆H₂₉N₅O₃
• 熔点: N/A
• 闪点: 333.447ºC

瑞维齐农用途

Revizinone是一个新的有选择性的phosphodiesterase (PDE) III抑制剂,在酶检测实验上的IC50值是0.036 microM。

瑞维齐农名称

• 中文名: 瑞维齐农
• 英文名: N-cyclohexyl-N-methyl-2-[(E)-[(2-oxo-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-7-yl)-phenylmethylidene]amino]oxyacetamide

瑞维齐农生物活性

• 描述: Revizinone是一个新的有选择性的phosphodiesterase (PDE) III抑制剂,在酶检测实验上的IC50值是0.036 microM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Herregods L et al. Haemodynamic effects of R 80122 immediately after cardiopulmonary bypass; preliminary results. Anaesthesia. 1994 Aug;49(8):719-22.

  [2]. Schneider J et al. Cardiac effects of R 79595 and its isomers (R 80122 and R 80123) in an acute heart failure model. A new class of cardiotonic agents with highly selective phosphodiesterase III inhibitory properties. Naunyn Schmiedebergs Arch Pharmacol. 1992 Nov;346(5):563-72.

  [3]. de Cheffoy de Courcelles D et al. Inhibition of human cardiac cyclic AMP-phosphodiesterases by R 80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds. J Pharmacol Exp Ther. 1992 Oct;263(1):6-14.

  [4]. Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22.

瑞维齐农物理化学性质

• 密度: 1.336g/cm3
• 沸点: 627.743ºC at 760 mmHg
• 分子式: C₂₆H₂₉N₅O₃
• 分子量: 459.54000
• 闪点: 333.447ºC
• 精确质量: 459.22700
• PSA: 86.60000
• LogP: 2.88190
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.677
• 储存条件: 2-8℃

瑞维齐农英文别名

• UNII-6208ZO6MLG
• Revizinone