94192-59-3

• 常用中文名：利沙齐农
• 常用英文名：Lixazinone
• CAS号：94192-59-3
• 分子式：C₂₁H₂₈N₄O₃
• 分子量：384.47200
• 发布时间：2018-03-30 08:00:00
• 更新时间：2024-01-10 17:15:11

名称

• 中文名: 利沙齐农
• 英文名: N-cyclohexyl-N-methyl-4-[(2-oxo-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-7-yl)oxy]butanamide
• 英文别名: Lixazinonum [Latin]; Butanamide,N-cyclohexyl-N-methyl-4-((1,2,3,5-tetrahydro-2-oxoimidazo(2,1-b)quinazolin-7-yl)oxy); Lixazinonum; Butanamide,N-cyclohexyl-N-methyl-4-((2-oxo-1,2,3,5-tetrahydroimidazo(2,1-b)quinazolin-7-yl)oxy); Lixazinone; N-cyclohexyl-N-methyl-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutyramide; Lixazinona; Lixazinona [Spanish]; Lixazinone [INN]

物化性质

• 密度: 1.33g/cm3
• 沸点: 579.2ºC at 760 mmHg
• 分子式: C₂₁H₂₈N₄O₃
• 分子量: 384.47200
• 闪点: 304.1ºC
• 精确质量: 384.21600
• PSA: 74.24000
• LogP: 2.27190
• 折射率: 1.659

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EJ3510100 CHEMICAL NAME : Butanamide, N-cyclohexyl-N-methyl-4-((2-oxo-1,2,3,5-tetrahydroimi dazo(2,1-b)quinazolin -7-yl) oxy)- CAS REGISTRY NUMBER : 94192-59-3 LAST UPDATED : 199806 DATA ITEMS CITED : 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4663320 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4663320

合成路线

94193-38-1 ~% 94192-59-3

文献：Venuti, Michael C.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.; Gu, Leo; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2145 - 2152

100-60-7 ~% 94192-59-3

文献：Jones; Venuti; Alvarez; Bruno; Berks; Prince Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 295 - 303

42454-06-8 ~% 94192-59-3

文献：Jones; Venuti; Alvarez; Bruno; Berks; Prince Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 295 - 303

94193-35-8 ~% 94192-59-3

文献：Jones; Venuti; Alvarez; Bruno; Berks; Prince Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 295 - 303

105763-67-5 ~% 94192-59-3

文献：Jones; Venuti; Alvarez; Bruno; Berks; Prince Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 295 - 303

94193-36-9 ~% 94192-59-3

文献：Jones; Venuti; Alvarez; Bruno; Berks; Prince Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 295 - 303

94193-37-0 ~% 94192-59-3

文献：Jones; Venuti; Alvarez; Bruno; Berks; Prince Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 295 - 303

114703-82-1 ~% 94192-59-3

文献：Venuti, Michael C.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.; Gu, Leo; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2145 - 2152

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