(2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺

更新时间：2024-01-01 21:42:41

(2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺结构式	常用名	(2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺	英文名	Sal003
	CAS号	1164470-53-4	分子量	463.208
	密度	1.5±0.1 g/cm3	沸点	N/A
	分子式	C₁₈H₁₅Cl₄N₃OS	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS09	信号词	Warning

用途

Sal003是eIF2_alpha_ phosphatase高效细胞渗透性抑制剂，Salubrinal的水溶性类似物。

中文名	(2E)-3-苯基-N-[2,2,2-三氯-1-[[[(4-氯苯基)氨基]硫代甲酰基]氨基]乙基]-2-丙烯酰胺
英文名	(2E)-3-Phenyl-N-(2,2,2-trichloro-1-{[(4-chlorophenyl)carbamothioy l]amino}ethyl)acrylamide
英文别名	更多

描述	Sal003是eIF2_alpha_ phosphatase高效细胞渗透性抑制剂,Salubrinal的水溶性类似物。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶研究领域 >> 癌症
参考文献	[1]. Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45. [2]. Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. [3]. Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.

描述

Sal003是eIF2_alpha_ phosphatase高效细胞渗透性抑制剂,Salubrinal的水溶性类似物。

相关类别

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

研究领域 >> 癌症

参考文献

[1]. Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45.

[2]. Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305.

[3]. Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.

密度	1.5±0.1 g/cm3
分子式	C₁₈H₁₅Cl₄N₃OS
分子量	463.208
精确质量	460.968994
PSA	95.78000
LogP	6.20
外观性状	粉末
折射率	1.694
储存条件	-20℃

符号	GHS09
信号词	Warning
危害声明	H410
警示性声明	P273-P501
危害码 (欧洲)	N
危险品运输编码	UN 3077 9 / PGIII

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