(4-氯苯基)[4-(8-硝基-5-喹啉基)-1-哌嗪基]甲酮

更新时间：2025-08-25 07:20:32

(4-氯苯基)[4-(8-硝基-5-喹啉基)-1-哌嗪基]甲酮结构式	常用名	(4-氯苯基)[4-(8-硝基-5-喹啉基)-1-哌嗪基]甲酮	英文名	B2
	CAS号	115687-05-3	分子量	396.83
	密度	1.4±0.1g/cm3	沸点	645.5±55.0°C at 760 mmHg
	分子式	C₂₀H₁₇ClN₄O₃	熔点	N/A
	MSDS	中文版美版	闪点	344.2±31.5°C
	符号	GHS06	信号词	Danger

用途

SIRT2-IN-8是一种有效的SIRT2抑制剂。SIRT2-IN-8可用于亨廷顿病和帕金森病研究[1]。

中文名	(4-氯苯基)[4-(8-硝基-5-喹啉基)-1-哌嗪基]甲酮
英文名	(4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone
英文别名	更多

描述	SIRT2-IN-8是一种有效的SIRT2抑制剂。SIRT2-IN-8可用于亨廷顿病和帕金森病研究[1]。
相关类别	信号通路 >> 表观遗传学 >> 抗衰老酶信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶研究领域 >> 神经疾病
靶点	SIRT2
参考文献	[1]. Bodner RA, Outeiro TF, Altmann S, et al. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proc Natl Acad Sci U S A. 2006;103(11):4246-4251.

密度	1.4±0.1g/cm3
沸点	645.5±55.0°C at 760 mmHg
分子式	C₂₀H₁₇ClN₄O₃
分子量	396.83
闪点	344.2±31.5°C
精确质量	396.09900
PSA	82.26000
LogP	4.28490
外观性状	solid brown
折射率	1.687
储存条件	2-8°C
水溶解性	Soluble to 100 mM in DMSO and to 10 mM in ethanol

MSDS英文版

符号	GHS06
信号词	Danger
危害声明	H301-H315-H319-H335
警示性声明	P261-P301 + P310-P305 + P351 + P338
个人防护装备	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲)	T
风险声明 (欧洲)	25-36/37/38
安全声明 (欧洲)	26-45
危险品运输编码	UN 2811 6.1 / PGIII
WGK德国	3

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CPNQ

BP 554 maleate

5-[4-(4-chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline B2

(4-Chlorophenyl)[4-(8-Nitro-5-Quinolinyl)-1-Piperazinyl]Methanone