105956-97-6

• 常用中文名：克林沙星
• 常用英文名：Clinafloxacin
• CAS号：105956-97-6
• 分子式：C₁₇H₁₇ClFN₃O₃
• 分子量：365.78700
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-03-23 08:00:00
• 更新时间：2026-07-03 08:32:20
• Clinafloxacin(PD-127391)是氟喹诺酮抗生素。

名称

• 中文名: 克林沙星
• 英文名: 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 中文别名: 克林沙星/可林沙星; Clinafloxacin试剂; 罗非考昔; 克林沙星盐酸盐溶液, 100PPM; 7-(3-氨基吡咯烷-1-基)-8-氯-1-环丙基-6-氟-4-氧代-1,4-二氢喹啉-3-羧酸; 1-环丙基-6-氟-7-(3-氨基吡咯烷-1-基)-8-氯-1,4-二氢-4-氧-喹啉-3-羧酸; 可林沙星; 1-环丙基-6-氟-7-(3-氨基吡咯烷-1- 基)-8-氯-1,4-二氢-4-氧-喹啉-3-羧酸; 克林沙星 105-6; 7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸; 克林沙星/可林沙星(产品不存在)
• 英文别名: Clinafloxacin in MeOH with 0.04M NaOH; 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydroxy-4-oxo-3-quinolinecboxylic acid; 3-Quinolinecboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo; Aids-007759; 7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecboxylic acid; 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecboxylic acid; Colinflosaxin; CLINAFLOXACIN; 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-3-quinolinecboxylic acid; Aids007759; 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid; Clinafloxacin CI96 AM1091; 7-(3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecboxylic acid, monohydrochloride; Clindamycin hydrochloride`Clinafloxacin; ClinafloxacinQ: What is Clinafloxacin Q: What is the CAS Number of Clinafloxacin; 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-cboxylic acid; CI-960; 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-cbox; 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecboxylic acid; Clinfloxacin; PD-127391; 105-8 (Hydrochloride); MFCD00865120; 6-Fluoro-8-chloro-1-cyclopropyl-7-(3-aminopyrrolidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-cboxylic acid; Clinafloxacin (AM-1091; Clinofloxacin; 7-(3-AMinopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-cboxylic acid; Clinafloxacin //BP; 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-Quinolin-3-cboxylic acid; 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-cboxyli

物化性质

• 密度: 1.573 g/cm3
• 沸点: 592.3ºC at 760 mmHg
• 熔点: 253-258ºC
• 分子式: C₁₇H₁₇ClFN₃O₃
• 分子量: 365.78700
• 闪点: 312ºC
• 精确质量: 365.09400
• PSA: 88.56000
• LogP: 3.12980
• 外观性状: 白色至淡黄色结晶粉末
• 蒸汽压: 7.14E-15mmHg at 25°C
• 折射率: 1.684
• 储存条件: 2-8°C

生物活性

• 描述: Clinafloxacin(PD-127391)是氟喹诺酮抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Humphrey, G.H., et al., Pharmacokinetics of clinafloxacin enantiomers in humans. J Clin Pharmacol, 1999. 39(11): p. 1143-50.

  [2]. Pan, X.S. and L.M. Fisher, DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother, 1998. 42(11): p. 2810-6.

  [3]. Jorgensen, J.H., et al., Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother, 2000. 44(11): p. 2962-8.

安全

• 符号: GHS08
• 信号词: Warning
• 危害声明: H361d
• 警示性声明: P281
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36
• 危险品运输编码: NONH for all modes of transport
• RTECS号: VB1800600
• 海关编码: 2933990090

合成路线

101987-89-7 ~% 105956-97-6

文献：Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991

105956-96-5 ~% 105956-97-6

文献：Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%