Clinafloxacin
Clinafloxacin structure
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Common Name | Clinafloxacin | ||
|---|---|---|---|---|
| CAS Number | 105956-97-6 | Molecular Weight | 365.78700 | |
| Density | 1.573 g/cm3 | Boiling Point | 592.3ºC at 760 mmHg | |
| Molecular Formula | C17H17ClFN3O3 | Melting Point | 253-258ºC | |
| MSDS | Chinese USA | Flash Point | 312ºC | |
| Symbol |
GHS08 |
Signal Word | Warning | |
Use of ClinafloxacinClinafloxacin(PD-127391) is a fluoroquinolone antibiotic.Target: AntibacterialClinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections [1]. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity [2]. Clinafloxacin is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3]. |
| Name | 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
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| Synonym | More Synonyms |
| Description | Clinafloxacin(PD-127391) is a fluoroquinolone antibiotic.Target: AntibacterialClinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections [1]. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity [2]. Clinafloxacin is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3]. |
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| Related Catalog | |
| References |
| Density | 1.573 g/cm3 |
|---|---|
| Boiling Point | 592.3ºC at 760 mmHg |
| Melting Point | 253-258ºC |
| Molecular Formula | C17H17ClFN3O3 |
| Molecular Weight | 365.78700 |
| Flash Point | 312ºC |
| Exact Mass | 365.09400 |
| PSA | 88.56000 |
| LogP | 3.12980 |
| Vapour Pressure | 7.14E-15mmHg at 25°C |
| Index of Refraction | 1.684 |
| InChIKey | QGPKADBNRMWEQR-UHFFFAOYSA-N |
| SMILES | NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1 |
| Storage condition | 2-8°C |
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Clinafloxacin CAS#:105956-97-6 |
| Literature: Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991 |
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Clinafloxacin CAS#:105956-97-6 |
| Literature: Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991 |
![8-chloro-1-cyclopropyl-6-fluoro-7-[3-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidin-1-yl]-4-oxoquinoline-3-carboxylic acid structure](https://image.chemsrc.com/caspic/102/105956-96-5.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Pharmacokinetics of danofloxacin and N-desmethyldanofloxacin in adult horses and their concentration in synovial fluid.
J. Vet. Pharmacol. Ther. 38(2) , 123-9, (2015) The objectives of this study were to investigate the pharmacokinetics of danofloxacin and its metabolite N-desmethyldanofloxacin and to determine their concentrations in synovial fluid after administr... |
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Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones.
J. Antimicrob. Chemother. 52(4) , 605-9, (2003) Garenoxacin is a novel des-F(6)-quinolone with good anti-anaerobe activity. The accumulation of garenoxacin and five other quinolones in the presence and absence of a variety of efflux pump inhibitors... |
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Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent.
J. Med. Chem. 51 , 3238-49, (2008) Novel pyrido[1,2,3- de][1,4]benzoxazine-6-carboxylic acid derivatives 5- 9 carrying a 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl moiety at the C-10 position were synthesized and their in vi... |
| MFCD00865120 |
| Clinafloxacin |
| 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid |