Clinafloxacin

Modify Date: 2024-01-02 10:41:47

Clinafloxacin Structure
Clinafloxacin structure
 Common Name Clinafloxacin
CAS Number 105956-97-6 Molecular Weight 365.78700
Density 1.573 g/cm3 Boiling Point 592.3ºC at 760 mmHg
Molecular Formula C17H17ClFN3O3 Melting Point 253-258ºC
MSDS Chinese USA Flash Point 312ºC
Symbol GHS08
GHS08		 Signal Word Warning

 Use of Clinafloxacin


Clinafloxacin(PD-127391) is a fluoroquinolone antibiotic.Target: AntibacterialClinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections [1]. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity [2]. Clinafloxacin is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3].

 Names

Name 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Synonym More Synonyms

 Clinafloxacin Biological Activity

Description Clinafloxacin(PD-127391) is a fluoroquinolone antibiotic.Target: AntibacterialClinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category currently in development for intravenous and oral therapy of serious infections [1]. Clinafloxacin is a novel fluoroquinolone with potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens. Clinafloxacin is highly active against S. pneumoniae 7785 (MIC, 0.125 μg/mL), and neither gyrA nor parC quinolone resistance mutations alone have much effect on this activity [2]. Clinafloxacin is identified as the most active fluoroquinolone against S. pneumoniae when compared with ofloxacin, levofloxacin, sparfloxacin, grepafloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3].
Related Catalog
References

[1]. Humphrey, G.H., et al., Pharmacokinetics of clinafloxacin enantiomers in humans. J Clin Pharmacol, 1999. 39(11): p. 1143-50.

[2]. Pan, X.S. and L.M. Fisher, DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother, 1998. 42(11): p. 2810-6.

[3]. Jorgensen, J.H., et al., Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother, 2000. 44(11): p. 2962-8.

 Chemical & Physical Properties

Density 1.573 g/cm3
Boiling Point 592.3ºC at 760 mmHg
Melting Point 253-258ºC
Molecular Formula C17H17ClFN3O3
Molecular Weight 365.78700
Flash Point 312ºC
Exact Mass 365.09400
PSA 88.56000
LogP 3.12980
Vapour Pressure 7.14E-15mmHg at 25°C
Index of Refraction 1.684
Storage condition 2-8°C

 Safety Information

Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H361d
Precautionary Statements P281
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
RTECS VB1800600
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles28

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Novel pyrido[1,2,3- de][1,4]benzoxazine-6-carboxylic acid derivatives 5- 9 carrying a 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl moiety at the C-10 position were synthesized and their in vi...

 Synonyms

MFCD00865120
Clinafloxacin
7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
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Related Compounds: More...
Clinafloxacin HCl
105956-99-8
Chemsrc provides Clinafloxacin(CAS#:105956-97-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Clinafloxacin are included as well.>> amp version: Clinafloxacin

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