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| 中文名 | 内皮素2 |
|---|---|
| 英文名 | h-cys-ser-cys-ser-ser-trp-leu-asp-lys-glu-cys-val-tyr-phe-cys-his-leu-asp-ile-ile-trp-oh |
| 英文别名 |
Endothelin 2,human
MFCD00133306 Endothelin-2,human Endothelin-2, human |
| 描述 | Endothelin-2, human是由21个氨基酸组成的血管活性肽,可与G蛋白连接的跨膜受体,ET-RA 和ET-RB 结合。 |
|---|---|
| 相关类别 | |
| 靶点 |
ET-RA, ET-RB[1] |
| 体外研究 | 在纳摩尔浓度下,内皮素-2表现出强烈且持久的血管收缩活性,特征是内皮素(EC50 = 0.52 nM)[1]。内皮素-2是巨噬细胞和THP-1单核细胞的化学引诱物,但不是新鲜分离的单核细胞。对内皮素-2的趋化反应显示出典型的钟形响应曲线。内皮素受体拮抗剂的实验表明,通过ET-RB受体介导向内皮素-2的迁移。肿瘤内皮素-2的表达可能调节巨噬细胞的行为,使活化的细胞在缺氧区域积聚[2]。 |
| 体内研究 | 两种不同的升压效应阶段通常见于内皮素-2：早期阶段紧随抑郁症反应,并在接下来的3-10分钟内占主导地位,而晚期升压效应在注射后10-20分钟发展并持续> 1小时[1]。 |
| 动物实验 | 大鼠[1]对于升压活性的测定，用氨基甲酸乙酯（1g / kg ip）麻醉重300-350g的雄性Wistar大鼠，并用阿托品（0.25mg / kg iv），普萘洛尔（1mg / kg iv）预处理。和bunazocine（1 mg / kg iv）。每3-4小时施用额外的维持剂量（初始剂量的一半）自主阻塞剂。每只动物仅给予一次内皮素-2大丸剂。从插入右股静脉的插管推注注射50μL缓冲液中的1nM内皮素-2。从套管记录血压，套管置于右颈动脉并连接到压力传感器[1]。 |
| 参考文献 |
| 分子式 | C115H160N26O32S4 |
|---|---|
| 分子量 | 2546.92000 |
| 精确质量 | 2545.06000 |
| PSA | 1025.62000 |
| LogP | 4.59880 |
| 外观性状 | powder | white |
| 储存条件 | 密封、在 -20ºC下保存 |
| 稳定性 | 如果遵照规格使用和储存则不会分解，未有已知危险反应 |
| 计算化学 | 1.疏水参数计算参考值（XlogP）:-2.6 2.氢键供体数量:33 3.氢键受体数量:39 4.可旋转化学键数量:46 5.互变异构体数量:998 6.拓扑分子极性表面积1030 7.重原子数量:177 8.表面电荷:0 9.复杂度:5550 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:23 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
| 更多 | 1. 性状：白色粉末 2. 密度（g/mL,20℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：未确定 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,KPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（Pa,20ºC）：未确定 12. 饱和蒸气压（KPa,20ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：未确定 |
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Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE Product identifiers Product name: Endothelin 2, human CAS-No.: 123562-20-9 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances Section2. HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Acute toxicity, Inhalation (Category 2) Acute toxicity, Dermal (Category 2) Acute toxicity, Oral (Category 2) Classification according to EU Directives 67/548/EEC or 1999/45/EC Very toxic by inhalation, in contact with skin and if swallowed. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal wordDanger Hazard statement(s) H300Fatal if swallowed. H310Fatal in contact with skin. H330Fatal if inhaled. Precautionary statement(s) P260Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264Wash hands thoroughly after handling. P280Wear protective gloves/ protective clothing. P284Wear respiratory protection. P302 + P350IF ON SKIN: Gently wash with plenty of soap and water. P310Immediately call a POISON CENTER or doctor/ physician. Supplemental Hazardnone Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R26/27/28Very toxic by inhalation, in contact with skin and if swallowed. S-phrase(s) S28After contact with skin, wash immediately with plenty of soap and water. S36/37Wear suitable protective clothing and gloves. S45In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Caution - substance not yet tested completely. Other hazards - none Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substances Formula: C115H160N26O32S4 Molecular Weight: 2.546,92 g/mol ComponentConcentration Endothelin 2, human CAS-No.123562-20-9- Section4. FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed Indication of any immediate medical attention and special treatment needed no data available Section5. FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Sulphur oxides Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available Section6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. Section7. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20 °C hygroscopic Store under inert gas. Specific end uses no data available Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Section9. PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) AppearanceForm: powder Colour: white b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evaporation rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Autoignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available Section10. STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available Section11. TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects InhalationMay be fatal if inhaled. May cause respiratory tract irritation. IngestionMay be fatal if swallowed. SkinMay be fatal if absorbed through skin. May cause skin irritation. EyesMay cause eye irritation. Additional Information RTECS: Not available Section12. ECOLOGICAL INFORMATION Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available Section13. DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. Section14. TRANSPORT INFORMATION UN number ADR/RID: 2811IMDG: 2811IATA: 2811 UN proper shipping name ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (Endothelin 2, human) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Endothelin 2, human) IATA:Toxic solid, organic, n.o.s. (Endothelin 2, human) Transport hazard class(es) ADR/RID: 6.1IMDG: 6.1IATA: 6.1 Packaging group ADR/RID: IIMDG: IIATA: I Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available SECTION 15 - REGULATORY INFORMATION N/A SECTION 16 - ADDITIONAL INFORMATION N/A |
| 符号 |
GHS06 |
|---|---|
| 信号词 | Danger |
| 危害声明 | H300 + H310 + H330 |
| 警示性声明 | P260-P264-P280-P284-P301 + P310-P302 + P350 |
| 个人防护装备 | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| 危害码 (欧洲) | T+ |
| 风险声明 (欧洲) | R26/27/28 |
| 安全声明 (欧洲) | S28-S45-S36-S37 |
| 危险品运输编码 | UN 2811 6.1/PG 1 |
| WGK德国 | 3 |