52-85-7

• 常用中文名：伐灭磷
• 常用英文名：American Cyanamid 38023
• CAS号：52-85-7
• 分子式：C₁₀H₁₆NO₅PS₂
• 分子量：325.341
• 相关类别： 分析化学 标准品 挥发性有机化合物(VOCs)
• 发布时间：2018-06-02 08:00:00
• 更新时间：2025-08-27 16:33:00
• Famphur is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an agrochemical, and an anthelminthic drug. Use of famphur as an insecticide is restricted.

名称

• 中文名: 伐灭磷
• 英文名: famphur
• 中文别名: 氨磺磷
• 英文别名: O-[4-(Dimethylsulfamoyl)phenyl] O,O-dimethyl phosphorothioate; Famofos; American Cyanamid CL 38023; MFCD00055307; Fanfos; Warbex; O-[4-(Dimethylsulfamoyl)phenyl]-O,O-dimethylthiophosphat; O,O-dimethyl-O-(4-dimethylsulfamoylphenyl)phosphorothioate; O-[4-[(dimethylamino)sulfonyl]phenyl] O,O-dimethyl phosphorothioate; 4-dimethoxyphosphinothioyloxy-N,N-dimethylbenzenesulfonamide; FAMOPHOS; O-4-dimethylsulfamoylphenyl O,O-dimethyl phosphorothioate; Famphos; Famophos warbex; Dovip; Phosphorothioic Acid O,O-Dimethyl Ester O-Ester with p-Hydroxy-N,N-dimethylbenzenesulfonamide; Thiophosphorsaeure-O,O'-dimethylester-O''-(4-dimethylsulfamoyl-phenylester); O-{4-[(dimethylamino)sulfonyl]phenyl} O,O-dimethyl thiophosphate; Phosphorothioic acid, O-[4-[(dimethylamino)sulfonyl]phenyl] O,O-dimethyl ester; Famphur; Famfur; EINECS 200-154-0; Thiophosphate de O-[4-(diméthylsulfamoyl)phényle] et de O,O-diméthyle; O,O-Dimethyl-O,p-(dimethylsulfamoyl)phenyl Phosphorothioate; Phosphorothioic Acid O-[4-[(Dimethylamino)sulfonyl]phenyl] O,O-Dimethyl Ester; Warbexol; O.O-Dimethyl-O-p-(dimethylsulfamoyl)-phenylphosphorothioat; American Cyanamid 38023

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 394.2±52.0 °C at 760 mmHg
• 熔点: -96ºC
• 分子式: C₁₀H₁₆NO₅PS₂
• 分子量: 325.341
• 闪点: 192.2±30.7 °C
• 精确质量: 325.020752
• PSA: 115.35000
• LogP: 2.13
• 外观性状: 液体
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.553
• 储存条件: 库房通风低温干燥,与食品原料分开储运
• 分子结构:

  1、 摩尔折射率：76.92

  2、 摩尔体积（m³/mol）：240.2

  3、 等张比容(90.2K)：641.9

  4、 表面张力(dyne/cm)：50.9

  5、 极化率(10-24cm³)：30.49

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:7

  4.可旋转化学键数量:6

  5.互变异构体数量:无

  6.拓扑分子极性表面积106

  7.重原子数量:19

  8.表面电荷:0

  9.复杂度:418

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：无色结晶

  2. 密度（g/mL,25/4℃）： 未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：55

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC, 13.33kpa）：

  7. 折射率： 未确定

  8. 闪点（ºC）： 未确定

  9. 比旋光度（º,）： 未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）： 未确定

  12. 饱和蒸气压（kPa,60ºC）： 未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：水中溶解度为100mg/L。可溶于二甲苯、氯仿、丙酮等溶剂中。

毒性和生态

毒理学数据: 1 、急性毒性：大鼠经口LD50：28mg/kg；大鼠，皮肤接触LD50：400mg/kg；小鼠经口LD50：9500ug/kg；小鼠腹腔LD50：11600ug/kg； 兔子，皮肤接触LD50：1460 mg/kg；野生鸟经口LD50：180ug/kg 2、其他多计量毒性：大鼠经口TDLo：13500ug/kg/90D-C CHEMICAL IDENTIFICATION RTECS NUMBER : TF7650000 CHEMICAL NAME : Phosphorothioic acid, O,O-dimethyl ester, O-ester with p-hydroxy-N,N-dimethylbenzene- sulfonamide CAS REGISTRY NUMBER : 52-85-7 LAST UPDATED : 199701 DATA ITEMS CITED : 14 MOLECULAR FORMULA : C10-H16-N-O5-P-S2 MOLECULAR WEIGHT : 325.36 WISWESSER LINE NOTATION : 1OPS&O1&OR DSWN1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 7,299,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 7,299,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 34,1697,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 11600 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 13,366,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1460 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JDAH "Organophosphorus Pesticides: Organic and Biological Chemistry," Eto, M., Cleveland, OH, CRC Press, Inc., 1974 Volume(issue)/page/year: -,299,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 59 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) REFERENCE : VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 54(12),94,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 64 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity REFERENCE : VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 54(12),94,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 1800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 13500 ug/kg/90D-C TOXIC EFFECTS : Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 50,167,1999 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

安全

• 符号: GHS07, GHS08
• 信号词: Warning
• 危害声明: H315-H319-H335-H336-H351-H373
• 警示性声明: P261-P281-P305 + P351 + P338
• 靶器官: Blood, Central nervous system, Liver
• 个人防护装备: Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
• 危害码 (欧洲): T
• 风险声明 (欧洲): R63
• 安全声明 (欧洲): 22-24/25-45-36/37-23-53
• 危险品运输编码: UN 2783
• RTECS号: TF7650000
• 包装等级: II
• 危险类别: 6.1(a)
• 海关编码: 2935009019

制备

可用二甲氧基硫代磷酰氯与对二甲氨基磺酰基苯酚反应制取。

海关

海关编码	2935009019
中文概述	2935009019 畜蜱磷,伐灭磷,地散磷等〔包括磺菌威,氰霜唑〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:35.0%
Summary	2935009019 o-(4-(n,n-dimethylsulfamoyl)phenyl) o,o-dimethyl phosphorothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:35.0%