3093-35-4

• 常用中文名：哈西奈德
• 常用英文名：Halcinonide
• CAS号：3093-35-4
• 分子式：C₂₄H₃₂ClFO₅
• 分子量：454.959
• 相关类别： 原料药 激素及调节内分泌功能类药 肾上腺皮质激素类药
• 发布时间：2018-06-12 12:43:16
• 更新时间：2026-06-30 17:56:39
• Halcinonide (SQ-18566) 是一糖皮质激素,用于治疗局部皮肤感染。

名称

• 中文名: 哈西奈德
• 英文名: halcinonide
• 中文别名: 氯氟舒松/氯氟松; 哈西奈德 标准品; 16a,17-[(1-甲基亚乙基)双氧]-11b-羟基-21-氯-9-氟孕甾-4-烯-3,20-二酮; 哈西奈德/Halcinonide; 哈西奈德溶液,100PPM; 哈西奈德杂质实验室出品; 氯氟舒松,10 MM DMSO 溶液; HALCINONIDE标准品; HALCIMAT|||HALCIDERM|||哈西奈德|||HALCINONIDA|||氯氟舒松|||SQ-18566; 哈西诺德; 哈西奈德检测标准品; 氯氟松; 哈西奈德对照品; 氯氟舒松; 氯氟舒松/氯氟松/哈西奈德; HALCINONIDE 哈西奈德 氯氟舒松 氯氟松; 嗜睡症; 甲醇中哈西奈德溶液标准物质; 哈西奈德 启步; 纯度; 硫酸原黄素; 2015,白色至微黄色结晶性粉末; 16A,17-[(1-甲基亚乙基)双氧]-11B-羟基-21-氯-9-氟孕甾-4-烯-3,20-二CHEMICALBOOK酮; 氯氟舒松 标准品
• 英文别名: Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α); (11β,16α)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)] pregn-4-ene-3,20-dione; Halcort; Adcortin; Pregn-4-ene-3,20-dione,21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-,(11beta,16alpha); halog; Halciderm; Halcinonide 2000; Halcinonide Impurity; (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(Chloracetyl)-4b-fluor-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; halciderm; Halcinonide, 10 mM in DMSO; EINECS 221-439-6; The sinai; MFCD00866006; Hasinonide; (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(Chloroacetyl)-4b-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; UNII:SI86V6QNEG; Halcinonida; Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11β,16α,17-trihydroxy-, cyclic 16,17-acetal with acetone (7CI, 8CI); HALCINONIDE; Halcimat|||Halciderm|||Halcinonida|||SQ-18566; halcimat; 21-Chloro-9α-fluoro-11β-hydroxy-16α,17α-(isopropylidenebisoxy)pregn-4-ene-3,20-dione; Alcinonide; 21-chloro-9-alpha-fluoro-11-beta-hydroxy-16-alpha,17-alpha-isopropylidenedioxypregn-4-ene-3,20-dione; (11β,16α)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]p; 21-Chloro-9a-fluoro-11b-hydroxy-16a,17a-isopropylidenedioxy-4-pregnene-3,20-dione; Halcimat; (11b,16a)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione; (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(chloroacétyl)-4b-fluoro-5-hydroxy-4a,6a,8,8-tétraméthyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tétradécahydro-2H-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-2-one; UNII-SI86V6QNEG; Pregn-4-ene-3,20-dione,21-chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(11b,16a); halcort; Halog; (6aS,6bR,7S,8aS,8bS,11,12aS,12bS)-8b-(2-chloroacetyl)-6b-fluoro-7-hydroxy-6a,8a,10,10-tetramethyl-5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one; Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy, cyclic-16,17-acetal with acetone; Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha); (11b,16a)-21-chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregn-4-ene-3,20-dione; halcinomide; lic16,17-acetalwithacetone; 20-dione,21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy-pregn-4-ene-cyc; Halcinonide //BP; 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 564.3±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₂ClFO₅
• 分子量: 454.959
• 闪点: 295.1±30.1 °C
• 精确质量: 454.192230
• PSA: 72.83000
• LogP: 3.31
• 外观性状: 白色到灰色 晶体 粉末
• 蒸汽压: 0.0±3.5 mmHg at 25°C
• 折射率: 1.567
• 储存条件: 室温

生物活性

• 描述: Halcinonide (SQ-18566) 是一糖皮质激素,用于治疗局部皮肤感染。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> SMO
  研究领域 >> 其他
• 参考文献:

  [1]. Pujos E, et al. Comparison of the analysis of corticosteroids using different techniques. Anal Bioanal Chem. 2005 Jan;381(1):244-54.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU5010200 CHEMICAL NAME : Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy-, cyclic 16,17-acetal with acetone CAS REGISTRY NUMBER : 3093-35-4 BEILSTEIN REFERENCE NO. : 1358242 LAST UPDATED : 199612 DATA ITEMS CITED : 13 MOLECULAR FORMULA : C24-H32-Cl-F-O5 MOLECULAR WEIGHT : 455.01 WISWESSER LINE NOTATION : T F5 E5 B666 GO IO RV PUTJ A1 BF CQ E1 FV1G H1 H1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 39800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 95500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 409 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4375 ug/kg/1W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Endocrine - changes in thymus weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4375 ug/kg/5W-I TOXIC EFFECTS : Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 455 mg/kg/13W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 45500 ug/kg/13W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 136 mg/kg/13W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - other changes MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 1 nmol/L REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,1782,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6056 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 794 (estimated) No. of Female Employees: 419 (estimated)

安全

• 符号: GHS08
• 信号词: Warning
• 危害声明: H361
• 警示性声明: P280
• 危害码 (欧洲): Xn:Harmful
• 风险声明 (欧洲): R63
• 安全声明 (欧洲): S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: TU5010200

合成路线

82427-96-1 ~67% 3093-35-4

文献：Annen, Klaus; Hofmeister, Helmut; Laurent, Henry; Wiechert, Rudolf Liebigs Annalen der Chemie, 1982 , # 5 p. 966 - 972

82427-95-0 ~% 3093-35-4

文献：Liebigs Annalen der Chemie, , # 5 p. 966 - 972

上下游产品

上游产品  2
82427-96-1 82427-95-0
下游产品  0