3093-35-4

• 常用中文名：哈西奈德
• 常用英文名：Halcinonide
• CAS号：3093-35-4
• 分子式：C₂₄H₃₂ClFO₅
• 分子量：454.959
• 相关类别： 原料药 激素及调节内分泌功能类药 肾上腺皮质激素类药
• 发布时间：2018-06-12 12:43:16
• 更新时间：2025-08-20 23:23:37
• Halcinonide (SQ-18566) 是一糖皮质激素,用于治疗局部皮肤感染。

名称

• 中文名: 哈西奈德
• 英文名: halcinonide
• 中文别名: 16a,17-[(1-甲基亚乙基)双氧]-11b-羟基-21-氯-9-氟孕甾-4-烯-3,20-二酮; 硫酸原黄素
• 英文别名: Alcinonide; Halcort; 21-Chloro-9a-fluoro-11b-hydroxy-16a,17a-isopropylidenedioxy-4-pregnene-3,20-dione; Halcimat; (11b,16a)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione; (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(chloroacétyl)-4b-fluoro-5-hydroxy-4a,6a,8,8-tétraméthyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tétradécahydro-2H-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-2-one; 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-(2-chloroacetyl)-4b-fluoro-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-5-hydroxy-4a,6a,8,8-tetramethyl-, (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-; UNII-SI86V6QNEG; Halciderm; 2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-(chloroacetyl)-4b-fluoro-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-5-hydroxy-4a,6a,8,8-tetramethyl-, (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-; Halog; (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(Chloracetyl)-4b-fluor-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; EINECS 221-439-6; halcinomide; Halcinonide; MFCD00866006; (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-6b-(Chloroacetyl)-4b-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; UNII:SI86V6QNEG

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 564.3±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₂ClFO₅
• 分子量: 454.959
• 闪点: 295.1±30.1 °C
• 精确质量: 454.192230
• PSA: 72.83000
• LogP: 3.31
• 外观性状: 白色到灰色 晶体 粉末
• 蒸汽压: 0.0±3.5 mmHg at 25°C
• 折射率: 1.567
• 储存条件: 室温

生物活性

• 描述: Halcinonide (SQ-18566) 是一糖皮质激素,用于治疗局部皮肤感染。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> SMO
  研究领域 >> 其他
• 参考文献:

  [1]. Pujos E, et al. Comparison of the analysis of corticosteroids using different techniques. Anal Bioanal Chem. 2005 Jan;381(1):244-54.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU5010200 CHEMICAL NAME : Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy-, cyclic 16,17-acetal with acetone CAS REGISTRY NUMBER : 3093-35-4 BEILSTEIN REFERENCE NO. : 1358242 LAST UPDATED : 199612 DATA ITEMS CITED : 13 MOLECULAR FORMULA : C24-H32-Cl-F-O5 MOLECULAR WEIGHT : 455.01 WISWESSER LINE NOTATION : T F5 E5 B666 GO IO RV PUTJ A1 BF CQ E1 FV1G H1 H1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 39800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 95500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 409 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4375 ug/kg/1W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Endocrine - changes in thymus weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4375 ug/kg/5W-I TOXIC EFFECTS : Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 455 mg/kg/13W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 45500 ug/kg/13W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 136 mg/kg/13W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - other changes MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 1 nmol/L REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,1782,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6056 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 794 (estimated) No. of Female Employees: 419 (estimated)

安全

• 符号: GHS08
• 信号词: Warning
• 危害声明: H361
• 警示性声明: P280
• 危害码 (欧洲): Xn:Harmful
• 风险声明 (欧洲): R63
• 安全声明 (欧洲): S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: TU5010200

合成路线

82427-96-1 ~67% 3093-35-4

文献：Annen, Klaus; Hofmeister, Helmut; Laurent, Henry; Wiechert, Rudolf Liebigs Annalen der Chemie, 1982 , # 5 p. 966 - 972

82427-95-0 ~% 3093-35-4

文献：Liebigs Annalen der Chemie, , # 5 p. 966 - 972

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