19057-60-4

• 常用中文名：薯蓣皂甙；薯蓣皂苷
• 常用英文名：Dioscin
• CAS号：19057-60-4
• 分子式：C₄₅H₇₂O₁₆
• 分子量：869.044
• 相关类别： 原料药 循环系统用药 防治心绞痛药
• 发布时间：2018-03-20 08:00:00
• 更新时间：2025-08-21 16:27:37
• Dioscin(CCRIS 4123; Collettiside III)是天然的植物来源的甾体皂苷,针对多种癌细胞有较好的抗癌活性。

名称

• 中文名: 薯蓣皂苷
• 英文名: dioscin
• 中文别名: 薯蓣皂甙; 重楼皂苷III
• 英文别名: (3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[6-deoxy-α-L-mannopyranosyl-(1->4)]-β-D-glucopyranoside; collettisideiii; (25R)-Spirost-5-en-3b-yl O-6-Deoxy-a-L-mannopyranosyl-(1®2)-O-[6-deoxy-a-L-mannopyranosyl-(1®4)]-b-D-glucopyranoside; β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[6-deoxy-α-L-mannopyranosyl-(1->4)]-; Dioscin; polyphyllin III; Diosgenin Bis-a-L-rhamnopyranosyl-(1®2 And 1®4)-b-D-Glucopyranoside

物化性质

• 密度: 1.4±0.1 g/cm3
• 熔点: 294-296 ℃
• 分子式: C₄₅H₇₂O₁₆
• 分子量: 869.044
• 精确质量: 868.482056
• PSA: 235.68000
• LogP: 7.24
• 折射率: 1.614
• 储存条件: 室温

生物活性

• 描述: Dioscin(CCRIS 4123; Collettiside III)是天然的植物来源的甾体皂苷,针对多种癌细胞有较好的抗癌活性。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 癌症
  天然产物 >> 类固醇
• 参考文献:

  [1]. Chen J, et al. Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family. J Huazhong Univ Sci Technolog Med Sci. 2014 Feb;34(1):125-30.

  [2]. Qu X, et al. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun. 2014 Jan 10;443(2):658-65.

  [3]. Qin J, et al. Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells. Drug Res (Stuttg). 2014 Jan;64(1):47-52.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LZ6405000 CHEMICAL NAME : beta-D-Glucopyranoside, (3-beta,25R)-spirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1- 2)-O-(6-deoxy-alpha-L-mannopyranosyl)-(1-4))- CAS REGISTRY NUMBER : 19057-60-4 LAST UPDATED : 199703 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C45-H72-O16 MOLECULAR WEIGHT : 869.17 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #91-271224

安全

• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 24/25
• 海关编码: 29389090