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63283-36-3生产厂家

63283-36-3价格

63283-36-3

63283-36-3结构式
63283-36-3结构式

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中文名 25-羟基维生素D3
英文名 Vitamin D3 25-hydroxy monohydrate
中文别名 骨化二醇,(5Z,7E)-9,10-开环胆甾-5,7,10(19)-三烯-3b,25-二醇一水合物
骨化二醇
英文别名 MFCD00867077
1H-Indene-1-pentanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-α,α,ε,7a-tetramethyl-, (εR,1R,3aS,4E,7aR)-, hydrate (1:1)
EINECS 242-990-9
Calcifediol hydrate
(3S,5Z,7E)-9,10-Secocholesta-5,7,10-triene-3,25-diol hydrate (1:1)
Calcifediol (monohydrate)
Calcifediol
描述 Calcifediol monohydrate 是维生素 D3 的主要循环代谢物, 是一种竞争性抑制剂,Ki 值为 3.9 μM。
相关类别
体外研究 脂质体或乙醇溶液中的Calcifediol对来自假单胞菌感染的鼠上皮细胞的促炎细胞因子KC的释放没有影响。用Calcifediol脂质体治疗感染的人支气管16-HBE细胞导致细菌存活率显着降低[1]。
参考文献

[1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22.

沸点 529.2ºC at 760 mmHg
分子式 C27H46O3
分子量 418.65
闪点 221.4ºC
PSA 40.46000
LogP 6.73390
外观性状 褐色,细粉末
蒸汽压 2.07E-13mmHg at 25°C
储存条件 −20°C

SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name: 25-Hydroxyvitamin D3 monohydrate
REACH No.: A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No.: 63283-36-3
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances



SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 2), H300
Acute toxicity, Inhalation (Category 1), H330
Acute toxicity, Dermal (Category 2), H310
Specific target organ toxicity - repeated exposure, Oral (Category 1), H372
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
T+ Very toxicR24/25, R26, R48/25
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal wordDanger
Hazard statement(s)
H300Fatal if swallowed.
H310Fatal in contact with skin.
H330Fatal if inhaled.
H372Causes damage to organs through prolonged or repeated exposure if
swallowed.
Precautionary statement(s)
P260Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264Wash hands thoroughly after handling.
P280Wear protective gloves/ protective clothing.
P284Wear respiratory protection.
P301 + P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/
physician.
P302 + P350IF ON SKIN: Gently wash with plenty of soap and water.
Supplemental Hazardnone
Statements
Other hazards
Lachrymator.

SECTION 3: Composition/information on ingredients
Substances
Synonyms: 25-Hydroxycholecalciferol
Formula: C27H44O2 · H2O
Molecular Weight: 418,65 g/mol
CAS-No.: 63283-36-3
Hazardous ingredients according to Regulation (EC) No 1272/2008
ComponentClassificationConcentration
25-Hydroxyvitamin D3 monohydrate
CAS-No.63283-36-3Acute Tox. 2; Acute Tox. 1;<= 100 %
Acute Tox. 2; STOT RE 1;
H300, H310, H330, H372
Hazardous ingredients according to Directive 1999/45/EC
ComponentClassificationConcentration
25-Hydroxyvitamin D3 monohydrate
CAS-No.63283-36-3T+, R24/25 - R26 - R48/25<= 100 %
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: -20 °C
Light sensitive. Store under inert gas.
Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
contact the supplier of the CE approved gloves. This recommendation is advisory only and must
be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
anticipated use by our customers. It should not be construed as offering an approval for any
specific use scenario.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
respirators and components tested and approved under appropriate government standards such
as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) AppearanceForm: solid
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezingno data available
point
f) Initial boiling point and no data available
boiling range
g) Flash pointno data available
h) Evapouration rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative densityno data available
n) Water solubilityinsoluble
o) Partition coefficient: n- log Pow: 9,4
octanol/water
p) Auto-ignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available

SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents, Acid chlorides, Acid anhydrides
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 35 - 47 mg/kg
LD50 Oral - rat - 42 mg/kg
LC50 Inhalation - rat - 4 h - 130 - 380 ppm
LD50 Dermal - rat - 61 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
25-HYDROXYCHOLECALCIFEROL is a analog of Vitamin D and may affect fetal development. Medical
studies indicate an "increased rate of fetal abnormalities" as a result of high doses of Vitamin D given
during pregancy.
Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Ingestion - Causes damage to organs through prolonged or repeated exposure.
Aspiration hazard
no data available
Additional Information
RTECS: Not available
Nausea, Vomiting, Diarrhoea, Headache, Dizziness, Weakness, To the best of our knowledge, the
chemical, physical, and toxicological properties have not been thoroughly investigated.

SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information
UN number
ADR/RID: 2811IMDG: 2811IATA: 2811
UN proper shipping name
ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (25-Hydroxyvitamin D3 monohydrate)
IMDG: TOXIC SOLID, ORGANIC, N.O.S. (25-Hydroxyvitamin D3 monohydrate)
IATA:Toxic solid, organic, n.o.s. (25-Hydroxyvitamin D3 monohydrate)
Transport hazard class(es)
ADR/RID: 6.1IMDG: 6.1IATA: 6.1
Packaging group
ADR/RID: IIIMDG: IIIATA: II
Environmental hazards
ADR/RID: noIMDG Marine pollutant: noIATA: no
Special precautions for user
no data available



SECTION 15 - REGULATORY INFORMATION
N/A


SECTION 16 - ADDITIONAL INFORMATION
N/A
符号 GHS02 GHS07
GHS02, GHS07
信号词 Danger
危害声明 H225-H319
警示性声明 P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235
个人防护装备 Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲) T+:Very toxic
风险声明 (欧洲) R28
安全声明 (欧洲) 28-36/37-45
危险品运输编码 UN 2811 6.1/PG 2
WGK德国 3