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| 中文名 | 盐酸阿米洛利二水合物 |
|---|---|
| 英文名 | amiloride hydrochloride dihydrate |
| 中文别名 |
3,5-二氨基-N-(氨基亚氨甲基)-6-氯哌嗪甲酰胺盐酸盐二水合物
盐酸阿米洛利 盐酸阿米洛利二水 |
| 英文别名 |
Modamide
Amiloride hydrochloride dihydrate AMILORIDEHYDROCHLORIDE,USP UNII-FZJ37245UC 3,5-Diamino-N-carbamimidoyl-6-chloro-2-pyrazinecarboxamide hydrochloride dihydrate Midamor Miloride hydrochloride dihydrate AMILORIDE HYDROCHLORIDE 2-HYDRATE 2-Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, hydrochloride, hydrate (1:1:2) AMILORIDE HCL DIHYDRATE |
| 描述 | Amiloride hydrochloride dihydrate 是上皮钠通道 (ENaC) 和尿激酶型纤溶酶原激活物受体 (uTPA) 的抑制剂。 |
|---|---|
| 相关类别 | |
| 靶点 |
ENaC[1], uTPA[2] |
| 体内研究 | 阿米洛利盐酸盐二水合物是有效的上皮钠通道(ENaCs)阻断剂。在注射后15至30分钟,阿米洛利在血浆中高度浓缩。与基线测量值相比,2mg/kg剂量的盐酸阿米洛利二水合物对血压,心率,肠系膜血管阻力或后躯血管阻力没有影响(n = 7)。在2小时内,与基线水平相比,阿米洛利盐酸盐二水合物引起动脉压(-1±1mmHg)和心率(-10±6bpm/min)的反应可忽略不计。结果显示阿米洛利盐酸盐二水合物剂量相关的反应模式,用于在postrema(AP)区域中的c-Fos活化。即使在最低剂量的盐酸阿米洛利二水合物(0.1mg/kg)中,AP中c-Fos标记的神经元的数量与对照大鼠在p <0.01水平上有统计学差异[1]。 |
| 动物实验 | 在雄性和雌性Sprague-Dawley大鼠上进行实验，所述大鼠已经保持在保持在23℃的热控制室中，具有12h / 12h光暗时间表。用阿米洛利盐酸盐二水合物（0.1,0.5和2.0mg / kg）腹膜内注射总共116只成年大鼠。注射后15,30,45或120分钟后，用8％水合氯醛麻醉大鼠，打开胸腔，通过心脏穿刺获得血液样品。将血液以5000RPM离心5分钟，分离血浆（1.5mL）并在-80℃下储存[1]。 |
| 参考文献 |
| 沸点 | 628.1ºC at 760 mmHg |
|---|---|
| 熔点 | >240℃ |
| 分子式 | C6H13Cl2N7O3 |
| 分子量 | 302.118 |
| 闪点 | 333.7ºC |
| 精确质量 | 301.045685 |
| PSA | 175.25000 |
| LogP | 1.94440 |
| 外观性状 | 浅黄色-黄色 绿色 晶体- 粉末 |
| 蒸汽压 | 1.08E-15mmHg at 25°C |
| 储存条件 | -20°C |
| 计算化学 | 1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:7 3.氢键受体数量:7 4.可旋转化学键数量:1 5.互变异构体数量:33 6.拓扑分子极性表面积161 7.重原子数量:18 8.表面电荷:0 9.复杂度:279 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:4 |
| 更多 | 1. 性状：不确定 2. 密度（g/mL,25/4℃）：不确定 3. 相对蒸汽密度（g/mL,空气=1）：不确定 4. 熔点（ºC）：不确定 5. 沸点（ºC,常压）：不确定 6. 沸点（ºC, 5.2kPa）：不确定 7. 折射率：不确定 8. 闪点（ºC）：不确定 9. 比旋光度（º）：不确定 10. 自燃点或引燃温度（ºC）：不确定 11. 蒸气压（kPa,25ºC）：不确定 12. 饱和蒸气压（kPa,60ºC）：不确定 13. 燃烧热（KJ/mol）：不确定 14. 临界温度（ºC）：不确定 15. 临界压力（KPa）：不确定 16. 油水（辛醇/水）分配系数的对数值：不确定 17. 爆炸上限（%,V/V）：不确定 18. 爆炸下限（%,V/V）：不确定 19. 溶解性：不确定 |
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Section 1. Chemical Product and Company Identification Amiloride HClCatalog AM122 Common Name/ Number(s). Trade Name CAS#17440-83-4
Manufacturer RTECSUQ2278500 SPECTRUM QUALITY PRODUCTS INC. TSCATSCA 8(b) inventory: No products were found. Commercial Name(s)Not available. CI# Not available. Synonym3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide IN CASE OF EMERGENCY hydrochloride Chemical NameNot available. Not available.CALL (310) 516-8000 Chemical Family Chemical FormulaC6H8ClN7O.HCl.2H2O SPECTRUM QUALITY PRODUCTS INC. Section 2.Composition and Information on Ingredients Exposure Limits TWA (mg/m3)STEL (mg/m3) CEIL (mg/m3) NameCAS #% by Weight 1) Amiloride HCl17440-83-4100 Toxicological DataAmiloride HCl on IngredientsLD50: Not available. LC50: Not available. Section 3. Hazards Identification Potential Acute Health Effects Very hazardous in case of ingestion. Hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. Potential Chronic HealthVery hazardous in case of ingestion. EffectsHazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Amiloride HCl Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Skin ContactIn case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Serious Skin ContactWash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds. Fire Hazards in Presence of Not available. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Amiloride HCl Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and show the label when possible. Avoid contact with skin and eyes. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid.OdorOdorless. Not available. Taste Molecular Weight302.12 g/mole Yellow. Color Not available. pH (1% soln/water) Boiling PointNot available. Melting PointDecomposition temperature: 286°C (546.8°F) Critical TemperatureNot available. Specific GravityNot available. Not applicable. Vapor Pressure Vapor DensityNot available. Not available. Volatility Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesNot available. SolubilityNot available. Section 10. Stability and Reactivity Data StabilityThe product is stable. Instability TemperatureNot available. Conditions of InstabilityNot available. Incompatibility with variousNot available. substances CorrosivityNon-corrosive in presence of glass. Amiloride HCl Special Remarks onNot available. Reactivity Special Remarks onNot available. Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryEye contact. Inhalation. Ingestion. Toxicity to AnimalsLD50: Not available. LC50: Not available. Chronic Effects on Humans Not available. Other Toxic Effects onVery hazardous in case of ingestion. HumansHazardous in case of skin contact (irritant), of inhalation. Special Remarks onNot available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherNot available. Toxic Effects on Humans Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are more toxic. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste Disposal Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Special Provisions forNot applicable. Transport DOT (Pictograms) Amiloride HCl Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations California Proposition 65 Warnings Other RegulationsNot available. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)R36/38- Irritating to eyes and skin. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles. SECTION 16 - ADDITIONAL INFORMATION N/A |
| 危害码 (欧洲) | Xi |
|---|---|
| 危险品运输编码 | NONH for all modes of transport |
| 海关编码 | 2933599090 |
| 海关编码 | 2933599090 |
|---|---|
| 中文概述 | 2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |