5577-13-9

• 常用中文名：N-(4-甲基苯基)磺酰氨基甲酸乙酯
• 常用英文名：Ethyl [(4-methylphenyl)sulfonyl]carbamate
• CAS号：5577-13-9
• 分子式：C₁₀H₁₃NO₄S
• 分子量：243.279
• 相关类别： 信号通路 跨膜转运 钾通道
• 发布时间：2018-12-18 13:44:21
• 更新时间：2024-01-02 12:06:37
• Ethyl tosylcarbamate 是合成 Gliclazide (G409877) 的中间体。Gliclazide 是全细胞的 β 细胞 ATP 敏感型钾流 (potassium currents) 阻断剂,IC50 为 184 nM。

名称

• 中文名: N-(4-甲基苯基)磺酰氨基甲酸乙酯
• 英文名: Ethyl N-(4-methylphenyl)sulfonylcarbamate
• 中文别名: 岱蜜克龙杂质C; 4-甲基苯磺酰基 氨基甲酸乙酯
• 英文别名: Tosylcarbamic acid ethyl ester; Ethyl [(4-methylphenyl)sulfonyl]carbamate; ethyl N-(4-toluenesulfonyl)carbamate; ethyl tosylcarbaMate; Ethyl [(4-methylphenyl)sulphonyl]carbamate; Carbamic acid, N-[(4-methylphenyl)sulfonyl]-, ethyl ester; Tosylurethane; ethoxycarbonamide of p-toluenebenzenesulfoacid; ethyl p-tosylcarbamate; (toluene-4-sulfonyl)-carbamic acid ethyl ester; ethyl N-(tosyl)carbamate; Carbamic acid, [(4-methylphenyl)sulfonyl]-, ethyl ester; N-(4-methylphenyl)sulfonylcarbamic acid ethyl ester; 2OVMSWR D1; N-(p-Tolylsulfonyl)carbamic acid ethyl ester

物化性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₁₀H₁₃NO₄S
• 分子量: 243.279
• 精确质量: 243.056534
• PSA: 80.85000
• LogP: 1.86
• 折射率: 1.530
• 储存条件: 室温，干燥

生物活性

• 描述: Ethyl tosylcarbamate 是合成 Gliclazide (G409877) 的中间体。Gliclazide 是全细胞的 β 细胞 ATP 敏感型钾流 (potassium currents) 阻断剂,IC50 为 184 nM。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 参考文献:

  [1]. Holmes B, et al. Gliclazide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in diabetes mellitus. Drugs. 1984 Apr;27(4):301-27.

  [2]. Rebecka Isaksson, et al. Rapid and straightforward transesterification of sulfonyl carbamates. Tetrahedron Letters, 57(13), 1476–1478.

  [3]. Shimoyama, T., et al., Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation. Metabolism, 2006. 55(6): p. 722-30.

安全

• 危害码 (欧洲): Xi
• 海关编码: 2935009090

合成路线

541-41-3 70-55-3 ~88% 5577-13-9

文献：Xi, Pin-xian; Xu, Zhi-hong; Liu, Xiao-hui; Cheng, Feng-juan; Zeng, Zheng-zhi Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2008 , vol. 71, # 2 p. 523 - 528 Title/Abstract Full Text View citing articles Show Details Xi, Pin-Xian; Xu, Zhi-Hong; Liu, Xiao-Hui; Chen, Feng-Juan; Huang, Liang; Zeng, Zheng-Zhi Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 541 - 546

4083-64-1 ~% 5577-13-9

文献：US5326796 A1, ;

5219-81-8 105-58-8 ~91% 5577-13-9

文献：Guo, Xiaoguang; Shang, Jianpeng; Li, Jian; Wang, Liguo; Ma, Yubo; Shi, Feng; Deng, Youquan Synthetic Communications, 2011 , vol. 41, # 8 p. 1102 - 1111

70-55-3 1608-26-0 ~33% 5577-13-9

文献：Bittner, Shmuel; Assaf, Yonit; Krief, Penina; Pomerantz, Martin; Ziemnicka, Barbara T.; Smith, Christina G. Journal of Organic Chemistry, 1985 , vol. 50, # 10 p. 1712 - 1718

10439-23-3 ~% 5577-13-9

文献：J. Gen. Chem. USSR (Engl. Transl.), , vol. 31, p. 2381 - 2385,2218 - 2222

93506-31-1 ~% 5577-13-9

文献：J. Gen. Chem. USSR (Engl. Transl.), , vol. 31, p. 2381 - 2385,2218 - 2222

上下游产品

上游产品  7
541-41-3 70-55-3 4083-64-1 5219-81-8
105-58-8 1608-26-0 10439-23-3
下游产品  7
4083-64-1 28490-28-0 28490-61-1 28490-23-5
70-55-3 32234-75-6 664-95-9

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%