168555-66-6

• 常用中文名：康普瑞汀磷酸二钠
• 常用英文名：Combretastatin A4 disodium phosphate
• CAS号：168555-66-6
• 分子式：C₁₈H₁₉Na₂O₈P
• 分子量：440.292
• 相关类别： 原料药 抗肿瘤药 其它抗肿瘤药
• 发布时间：2018-04-26 08:00:00
• 更新时间：2024-01-08 16:41:27
• Fosbretabulin(CA 4DP; CA 4P)二钠是微管去稳定剂,能靶向损伤血管。

名称

• 中文名: 考布他丁 A-4 磷酸二钠盐
• 英文名: disodium,[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate
• 中文别名: 康布瑞汀磷酸二钠; 康普瑞汀磷酸二钠
• 英文别名: Fosbretabulin disodium; Phenol, 2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, dihydrogen phosphate, sodium salt (1:2); Fosbretabulin disodium (USAN); Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium; Combretastatin A-4 phosphate; Zybrestat; Disodium 2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]phenyl phosphate; CA4DP; Combretastatin A4 disodium phosphate; Fosbretabulin (disodium); CoMbretastatin A4 Phosphate DisodiuM Salt

物化性质

• 沸点: 611.8ºC at 760 mmHg
• 熔点: 238-242ºC
• 分子式: C₁₈H₁₉Na₂O₈P
• 分子量: 440.292
• 精确质量: 440.061279
• PSA: 119.15000
• LogP: 4.23930
• 外观性状: 白色固体
• 蒸汽压: 7.99E-16mmHg at 25°C
• 储存条件: Refrigerator
• 水溶解性: H2O: soluble5mg/mL, clear

生物活性

• 描述: Fosbretabulin(CA 4DP; CA 4P)二钠是微管去稳定剂,能靶向损伤血管。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Shen CH, Shee JJ, Wu JY, Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model. Br J Pharmacol. 2010 Aug;160(8):2008-27.

  [2]. Zhang C, Zhou SS, Li XR, Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo. Oncol Rep. 2013 Jun;29(6):2275-82.

  [3]. Ke Q, Bodyak N, Rigor DL, Pharmacological inhibition of the hypertensive response to combretastatin A-4 phosphate in rats. Vascul Pharmacol. 2009 Nov-Dec;51(5-6):337-43.

  [4]. Mooney CJ, Nagaiah G, Fu P, A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome. Thyroid. 2009 Mar;19(3):233-40.

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport