758-17-8

• 常用中文名：N-甲基甲酰肼
• 常用英文名：N-FORMYL-N-METHYLHYDRAZINE
• CAS号：758-17-8
• 分子式：C₂H₆N₂O
• 分子量：74.08180
• 发布时间：2016-06-10 23:22:18
• 更新时间：2025-08-26 17:28:54

名称

• 中文名: N-甲基甲酰肼
• 英文名: N-amino-N-methylformamide
• 英文别名: Hydrazine,1-formyl-1-methyl; N-METHYL-N-FORMYLHYDRAZINE; 1-Methyl-1-formylhydrazide; Methylformylhydrazine; 2-Methyl-2-formylhydrazine; 1-Formyl-1-methylhydrazin; Formic acid,methylhydrazide; N-amino-N-methyl-formamide; Formic acid,1-methylhydrazide; N-methylformic hydrazide; N-formyl-N-methylhydrazine; 1-formyl-1-methylhydrazine; 1-methyl-1-formyl-hydrazine; 1-Methylformylhydrazine

物化性质

• 密度: 1.061g/cm3
• 沸点: 118.6ºC at 760 mmHg
• 熔点: 219-222 °C
• 分子式: C₂H₆N₂O
• 分子量: 74.08180
• 闪点: 25.5ºC
• 精确质量: 74.04800
• PSA: 46.33000
• LogP: 0.28450
• 外观性状: 无色至黄色液体
• 折射率: 1.45
• 储存条件: 2-8°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LQ8940000 CHEMICAL NAME : Formic acid, methylhydrazide CAS REGISTRY NUMBER : 758-17-8 LAST UPDATED : 199612 DATA ITEMS CITED : 16 MOLECULAR FORMULA : C2-H6-N2-O MOLECULAR WEIGHT : 74.10 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 118 mg/kg TOXIC EFFECTS : Behavioral - excitement Liver - other changes Kidney, Ureter, Bladder - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 14 mg/kg/62W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg/40W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 6100 mg/kg/80W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7840 mg/kg/70W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3360 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3158 mg/kg/94W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3920 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 64 mg/kg/80W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 84 mg/kg/70W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 187 mg/kg/78W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 158 mg/kg/79W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 umol/plate REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 26,155,1983

安全

• 危害码 (欧洲): T+

合成路线

60-34-4 109-94-4 ~76% 758-17-8 155106-68-6

文献：Delalu, Henri; Sabate, Carlos Miro Chemistry - An Asian Journal, 2012 , vol. 7, # 4 p. 715 - 724

64-18-6 60-34-4 ~90% 758-17-8

文献：Werner, Wolfgang; Depreux, Patrick Journal of Chemical Research, Miniprint, 1980 , # 11 p. 4513 - 4521

16694-46-5 60-34-4 ~% 758-17-8

文献：Kohn,H.; Olofson,R.A. Journal of Organic Chemistry, 1972 , vol. 37, # 22 p. 3504 - 3509

60-34-4 109-94-4 ~% 758-17-8

文献：Pedersen,C.T. Acta Chemica Scandinavica (1947-1973), 1964 , vol. 18, p. 2199 - 2200

107-31-3 60-34-4 ~% 758-17-8

文献：Dorn,H. et al. Chemische Berichte, 1965 , vol. 98, p. 3377 - 3384 Show Details Zinner,G.; Gebhardt,U. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, 1971 , vol. 304, p. 706 - 712

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