139-41-3

• 常用中文名：N,N'-二(2-羟乙基)甘氨酸钠
• 常用英文名：sodium N,N-bis(2-hydroxyethyl)glycinate
• CAS号：139-41-3
• 分子式：C₆H₁₂NNaO₄
• 分子量：185.15400
• 相关类别： 生物化工 氨基酸及其衍生物 甘氨酸类衍生物
• 发布时间：2019-02-01 17:51:39
• 更新时间：2025-08-24 20:26:46

名称

• 中文名: N,N’-二(2-羟乙基)甘氨酸钠
• 英文名: sodium,2-[bis(2-hydroxyethyl)amino]acetate
• 中文别名: N,N-双(2-羟基乙基)甘氨酸钠; N,N'-二(2-羟乙基)甘氨酸钠
• 英文别名: EINECS 205-360-4; MFCD00065943; Sodium dihydroxyethylglycinate; Bicine sodium salt

物化性质

• 密度: 1.2 g/mL at 25 °C
• 沸点: 388.5ºC at 760mmHg
• 分子式: C₆H₁₂NNaO₄
• 分子量: 185.15400
• 闪点: 188.8ºC
• 精确质量: 185.06600
• PSA: 83.83000
• 折射率: n20/D 1.413
• 储存条件:

  保持贮藏器密封、储存在阴凉、干燥的地方，确保工作间有良好的通风或排气装置

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应

• 分子结构:

  1、摩尔折射率：无可用的

  2、摩尔体积（cm³/mol）：无可用的

  3、等张比容（90.2K）：无可用的

  4、表面张力（dyne/cm）：无可用的

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：无可用的

  7、单一同位素质量：185.066403 Da

  8、标称质量：185 Da

  9、平均质量：185.1535 Da

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:5

  4.可旋转化学键数量:6

  5.互变异构体数量:无

  6.拓扑分子极性表面积83.8

  7.重原子数量:12

  8.表面电荷:0

  9.复杂度:116

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  1. 性状：未确定

  2. 密度（g/mL,25℃）：1.2

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,0.4KPa）：未确定

  7. 折射率：n20/D 1.413

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（mmHg,25ºC）：未确定

  12. 饱和蒸气压（kPa,20ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifiers Product name: Bicine sodium salt REACH No.: A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. CAS-No.: 139-41-3 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances SECTION 2: Hazards identification Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Skin corrosion (Category 1A), H314 Specific target organ toxicity - single exposure (Category 3), H335 Specific target organ toxicity - repeated exposure (Category 2), H373 Acute aquatic toxicity (Category 1), H400 For the full text of the H-Statements mentioned in this Section, see Section 16. Classification according to EU Directives 67/548/EEC or 1999/45/EC C CorrosiveR35 Xn HarmfulR48/22 N Dangerous for theR50 environment For the full text of the R-phrases mentioned in this Section, see Section 16. Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal wordDanger Hazard statement(s) H314Causes severe skin burns and eye damage. H335May cause respiratory irritation. H373May cause damage to organs through prolonged or repeated exposure. H400Very toxic to aquatic life. Precautionary statement(s) P261Avoid breathing vapours. P273Avoid release to the environment. P280Wear protective gloves/ protective clothing/ eye protection/ face protection. P305 + P351 + P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310Immediately call a POISON CENTER or doctor/ physician. Supplemental Hazardnone Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s)C Corrosive N Dangerous for the environment R-phrase(s) R35Causes severe burns. R48/22Harmful: danger of serious damage to health by prolonged exposure if swallowed. R50Very toxic to aquatic organisms. S-phrase(s) S26In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39Wear suitable protective clothing, gloves and eye/face protection. S45In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S61Avoid release to the environment. Refer to special instructions/ Safety data sheets. Other hazards - none SECTION 3: Composition/information on ingredients Mixtures Synonyms: N,N-Bis(2-hydroxyethyl)glycinesodium salt Formula: C6H12NNaO4 Molecular Weight: 185,15 g/mol Hazardous ingredients according to Regulation (EC) No 1272/2008 ComponentClassificationConcentration Sodium hydroxide CAS-No.1310-73-2Skin Corr. 1A; H31410 - 20 % EC-No.215-185-5 Index-No.011-002-00-6 Diethanolamine CAS-No.111-42-2Acute Tox. 4; STOT RE 2;10 - 20 % EC-No.203-868-0Skin Irrit. 2; Eye Dam. 1; Index-No.603-071-00-1H302, H315, H318, H373 Ammonium hydroxide CAS-No.1336-21-6Skin Corr. 1B; Aquatic Acute 10 - 20 % EC-No.215-647-61; H314, H400 Index-No.007-001-01-2 Sodium carbonate CAS-No.497-19-8Eye Irrit. 2; H31910 - 20 % EC-No.207-838-8 Index-No.011-005-00-2 Hazardous ingredients according to Directive 1999/45/EC ComponentClassificationConcentration Sodium hydroxide CAS-No.1310-73-2C, R3510 - 20 % EC-No.215-185-5 Index-No.011-002-00-6 Diethanolamine CAS-No.111-42-2Xn, R22 - R38 - R41 - R48/22 10 - 20 % EC-No.203-868-0 Index-No.603-071-00-1 Ammonium hydroxide CAS-No.1336-21-6C, N, R34 - R5010 - 20 % EC-No.215-647-6 Index-No.007-001-01-2 Sodium carbonate CAS-No.497-19-8Xi, R3610 - 20 % EC-No.207-838-8 Index-No.011-005-00-2 For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16 SECTION 4: First aid measures Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 Indication of any immediate medical attention and special treatment needed no data available SECTION 5: Firefighting measures Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Sodium oxides Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. SECTION 7: Handling and storage Precautions for safe handling Avoid inhalation of vapour or mist. For precautions see section 2.2. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Specific end use(s) A part from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. SECTION 9: Physical and chemical properties Information on basic physical and chemical properties a) AppearanceForm: liquid b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and no data available boiling range g) Flash pointnot applicable h) Evapouration rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative density1,2 g/mL at 25 °C n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Auto-ignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available SECTION 10: Stability and reactivity Reactivity no data available Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Zinc, Oxidizing agents, Strong oxidizing agents, Iron, Copper, Strong acids, Organic materials, Aluminum Hazardous decomposition products Other decomposition products - no data available In the event of fire: see section 5 SECTION 11: Toxicological information Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitisation no data available Germ cell mutagenicity no data available Carcinogenicity IARC:2B - Group 2B: Possibly carcinogenic to humans (Diethanolamine) Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Additional Information RTECS: Not available Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea Liver - Irregularities - Based on Human Evidence (Diethanolamine) SECTION 12: Ecological information Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted Other adverse effects Very toxic to aquatic life. SECTION 13: Disposal considerations Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. SECTION 14: Transport information UN number ADR/RID: 3267IMDG: 3267IATA: 3267 UN proper shipping name ADR/RID: CORROSIVE LIQUID, BASIC, ORGANIC, N.O.S. (Ammonium hydroxide, Diethanolamine, Sodium hydroxide) IMDG: CORROSIVE LIQUID, BASIC, ORGANIC, N.O.S. (Sodium hydroxide, Ammonium hydroxide, Diethanolamine) IATA:Corrosive liquid, basic, organic, n.o.s. (Sodium hydroxide, Ammonium hydroxide, Diethanolamine) Transport hazard class(es) ADR/RID: 8IMDG: 8IATA: 8 Packaging group ADR/RID: IIIIMDG: IIIIATA: III Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available SECTION 15 - REGULATORY INFORMATION N/A SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 根据国家和地方有关法规的要求处置。或与厂商或制造商联系，确定处置方法。 CHEMICAL IDENTIFICATION RTECS NUMBER : MB9105000 CHEMICAL NAME : Glycine, N,N-bis(2-hydroxyethyl)-, monosodium salt CAS REGISTRY NUMBER : 139-41-3 LAST UPDATED : 199701 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C6-H12-N-O4.Na

安全

• 危害码 (欧洲): C: Corrosive;
• 风险声明 (欧洲): R35
• 安全声明 (欧洲): 26-36/37/39-45
• 危险品运输编码: UN 3267 8/PG 3
• WGK德国: -