526-36-3

• 常用中文名：木霉唑啉
• 常用英文名：xylometazoline
• CAS号：526-36-3
• 分子式：C₁₆H₂₄N₂
• 分子量：244.38
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 肾上腺素能受体
• 发布时间：2018-08-14 00:35:15
• 更新时间：2024-01-06 17:35:58
• Xylometazoline 是一种 α-肾上腺素能受体激动剂 (Ki=0.05-1.7 μM)。Xylometazoline 可收缩鼻腔血管,增加鼻腔气流。Xylometazoline 可用于鼻塞和流鼻涕的研究。

名称

• 中文名: 赛洛唑啉
• 英文名: 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
• 中文别名: 2-(4-叔丁基-2,6-二甲基苄基)-4,5-二氢-1H-咪唑
• 英文别名: Novorin; 2-(4-tert-Butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazol; 2-(4-tert-butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole; Xylomethazoline; Otriven; Otrix; Xilometazolina; UNII-WPY40FTH8K; 2-[(4-t-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole; Otrivin; 2-[(2,6-dimethyl-4-tert-butylphenyl)methyl]-4,5-dihydro-1H-imidazole; Xylometazoline; Xylometazolinum; 2-(3,4-DIMETHOXY-PHENYL)-BENZO[D]IMIDAZO[2,1-B]-THIAZOLE-3-CARBALDEHYDE; Otrivine

物化性质

• 密度: 1g/cm3
• 沸点: 394.2ºC at 760mmHg
• 分子式: C₁₆H₂₄N₂
• 分子量: 244.38
• 闪点: 192.2ºC
• 精确质量: 244.19400
• PSA: 24.39000
• LogP: 2.90950
• 储存条件: -20°C

生物活性

• 描述: Xylometazoline 是一种 α-肾上腺素能受体激动剂 (Ki=0.05-1.7 μM)。Xylometazoline 可收缩鼻腔血管,增加鼻腔气流。Xylometazoline 可用于鼻塞和流鼻涕的研究。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 炎症/免疫
• 靶点:

  Alpha-1A adrenergic receptor:0.05 μM (Ki)

  Alpha-1B adrenergic receptor:0.30 μM (Ki)

  Alpha-1D adrenergic receptor:0.15 μM (Ki)

  Alpha-2A adrenergic receptor:0.88 μM (Ki)

  Alpha-2B adrenergic receptor:1.7 μM (Ki)

  Alpha-2C adrenergic receptor:0.19 μM (Ki)

• 参考文献:

  [1]. Ronald Eccles, et al. The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol. 2008 Sep-Oct;22(5):491-6.

  [2]. Britta Haenisch, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ2380000 CHEMICAL NAME : 2-Imidazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)- CAS REGISTRY NUMBER : 526-36-3 BEILSTEIN REFERENCE NO. : 0180524 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C16-H24-N2 MOLECULAR WEIGHT : 244.42 WISWESSER LINE NOTATION : T5M CN BUTJ B1R B1 F1 DX1&1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 215 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,729,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 46 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,729,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,971,1962

安全

• 海关编码: 2933290090

合成路线

84803-57-6 107-15-3 ~% 526-36-3

文献：CIBA Patent: US2868802 , 1957 ;

海关

海关编码	2933290090
中文概述	2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%