17090-79-8

17090-79-8结构式

常用中文名：莫能菌素
常用英文名：Monensin
CAS号：17090-79-8
分子式：C₃₆H₆₁NaO₁₁
分子量：670.871
相关类别：原料药抗寄生虫病药抗原虫药
发布时间：2018-02-15 08:00:00
更新时间：2024-01-04 12:14:25
Monensin 是由链霉菌属产生的脂溶性天然生物活性离子载体,它可以结合质子和一价阳离子。Monensin 在药物敏感和耐药菌株中均具有针对人类机会病原体的广谱活性。Monensin 能够诱导多种癌细胞系的凋亡。

中文名	莫能菌素
英文名	monensin A
中文别名	莫能星钠
英文别名	1,6-Dioxaspiro[4.5]decane-7-butanoic acid, 2-[(2S,2'R,3'S,5R,5'R)-2-ethyloctahydro-3'-methyl-5'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9- ;hydroxy-β-methoxy-α,γ,2,8-tetramethyl-, (αS,βR,γS,2S,5R,7S,8R,9S)- monensicacid Monensin Elancoban Monelan Romensin MONENSIN SODIUM 1,6-dioxaspiro[4.5]decane-7-butanoic acid, 2-[(2S,2'R,3'S,5R,5'R)-2-ethyloctahydro-3'-methyl-5'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9-hydroxy-b-methoxy-a,g,2,8-tetramethyl-, (aS,bR,gS,2S,5R,7S,8R,9S)- MONENSIN(PURE) MFCD00077826 EINECS 244-941-7 a3823a 1,6-dioxaspiro[4.5]decane-7-butanoic acid, 2-[(2S,2'R,3'S,5R,5'R)-2-ethyloctahydro-3'-methyl-5'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-, (αS,βR,γS,2S,5R,7S,8R,9S)- (2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-{(2S,2'R,3'S,5R,5'R)-2-Ethyl-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-3'-methyloctahydro-2,2'-bifuran-5-yl}-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid MONENSIN NA

描述	Monensin 是由链霉菌属产生的脂溶性天然生物活性离子载体,它可以结合质子和一价阳离子。Monensin 在药物敏感和耐药菌株中均具有针对人类机会病原体的广谱活性。Monensin 能够诱导多种癌细胞系的凋亡。
相关类别	信号通路 >> 细胞凋亡 >> 细胞凋亡研究领域 >> 癌症研究领域 >> 感染信号通路 >> 抗感染 >> 细菌
参考文献	[1]. Rajendran V, et, al. Chemotherapeutic Potential of Monensin as an Anti-microbial Agent. Curr Top Med Chem. 2018; 18(22): 1976-1986. [2]. Vanneste M, et, al. High content screening identifies monensin as an EMT-selective cytotoxic compound. Sci Rep. 2019 Feb 4; 9(1):1200.