87-00-3

87-00-3结构式
87-00-3结构式
  • 常用中文名:后马托品
  • 常用英文名:Homatropine
  • CAS号:87-00-3
  • 分子式:C16H21NO3
  • 分子量:275.34300
  • 相关类别: 原料药 神经系统用药 拟胆碱药
  • 发布时间:2018-03-23 08:00:00
  • 更新时间:2024-01-02 19:55:33
  • 霍马托品是一种口服活性毒蕈碱乙酰胆碱受体拮抗剂,可用作抗胆碱药[1]。

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中文名 后马托品
英文名 [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate
中文别名 扁桃酰托品碱
8-甲基-8-氮杂双环[3.2.1]辛烷-3-醇羟基(苯基)乙酸酯
英文别名 Omatropina [DCIT]
Homatropin
Homotropine
DL-mandelic acid-tropane-3endo-yl ester
Homoatropine
homatropine
Mandelyltropeine
Homatropine [BAN]
Methylhomatropinum
DL-Mandelsaeure-tropan-3endo-ylester
EINECS 201-716-8
homatropine hydrobromide
8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Mandelytropeine
MFCD00067305
描述 霍马托品是一种口服活性毒蕈碱乙酰胆碱受体拮抗剂,可用作抗胆碱药[1]。
相关类别
体外研究 霍马托品(20μM)单独在豚鼠心房中产生的剂量比为259,与溴化六甲铵(HY-B0569)联合在豚鼠心房时产生的剂量率仅为95.0[1]。Homatropine与胃中的毒蕈碱受体(pA2=7.13)和心房中的毒鼠碱受体(p A2=7.21)具有亲和力,反应速率(p A2=7.07)[2]。
体内研究 甲基溴化霍马托品(9 mm x 5 mm锥形栓剂)可迅速阻断迷走神经刺激对大鼠脉搏率和静脉注射乙酰胆碱对血压的影响[3]。动物模型:雄性白化大鼠[3]剂量:9 mm x 5 mm锥形栓剂给药:通过栓剂结果:阻断对迷走神经刺激和乙酰胆碱的心血管反应;插入栓剂后10-20分钟,在2-16Hz、5V范围内的迷走神经刺激对脉搏率的影响实际上被消除,并在45-60分钟保持不变。
密度 1.21 g/cm3
沸点 403.3ºC
熔点 100ºC
分子式 C16H21NO3
分子量 275.34300
闪点 197.7ºC
精确质量 275.15200
PSA 49.77000
LogP 1.82630

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YM5600000
CHEMICAL NAME :
1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, mandelate (ester)
CAS REGISTRY NUMBER :
87-00-3
BEILSTEIN REFERENCE NO. :
0087959
LAST UPDATED :
199712
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C16-H21-N-O3
MOLECULAR WEIGHT :
275.38
WISWESSER LINE NOTATION :
T56 A ANTJ A1 GOVYQR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,156,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1307 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2035763
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2035763
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2035763 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84350 No. of Facilities: 170 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2582 (estimated)

海关编码 2933990090

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87-00-3结构式

87-00-3

文献:Journal fuer Praktische Chemie (Leipzig), , vol. <2> 117, p. 147
海关编码 2933990090
中文概述 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%