- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：6-[4-(叔丁基)苯氧基]吡啶-3-胺
- 纯度：99.0%
- 规格：
- 联系人：徐经理
- 联系电话：13311869306
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：CB-103
- 纯度：98.9%
- 规格：1g
- 联系人：赖经理
- 联系电话：13564518121
- 上海脉铂医药科技有限公司
- 上海市 上海市 嘉定区
- 产品名：CB-103
- 纯度：98.0%
- 规格：10mg
- 联系人：李先生
- 联系电话：18916172912
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：CB-103
- 纯度：98.0%
- 规格：100mg/25mg/5mg/500mg
- 联系人：阿拉丁
- 联系电话：400-620-6333
查看所有供应商和价格请点击：
218457-67-1
218457-67-1结构式
- 常用中文名：6-[4-(叔丁基)苯氧基]吡啶-3-胺
- 常用英文名：5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- CAS号：218457-67-1
- 分子式：C15H18N2O
- 分子量：242.31600
- 相关类别： 信号通路 干细胞及 Wnt 通路 Notch
- 发布时间：2018-12-25 15:37:33
- 更新时间：2024-01-10 10:34:01
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CB-103 是一种 notch 信号通路抑制剂,被开发用于癌症治疗,详细信息请参考专利文献 US9296682B2。
| 中文名 | 6-[4-(叔丁基)苯氧基]吡啶-3-胺 |
|---|---|
| 英文名 | 6-(4-tert-butylphenoxy)pyridin-3-amine |
| 中文别名 | 5-氨基-2-(4-叔丁苯氧基)吡啶 |
| 英文别名 |
5-Amino-2-(4-tert-butylphenoxy)pyridine
6-(4-(tert-Butyl)phenoxy)pyridin-3-amine MFCD00052647 |
| 描述 | CB-103 是一种 notch 信号通路抑制剂,被开发用于癌症治疗,详细信息请参考专利文献 US9296682B2。 |
|---|---|
| 相关类别 | |
| 参考文献 |
| 密度 | 1.09g/cm3 |
|---|---|
| 沸点 | 394.2ºC at 760mmHg |
| 熔点 | 89-90ºC |
| 分子式 | C15H18N2O |
| 分子量 | 242.31600 |
| 闪点 | 192.2ºC |
| 精确质量 | 242.14200 |
| PSA | 48.14000 |
| LogP | 4.33480 |
| 蒸汽压 | 2.01E-06mmHg at 25°C |
| 折射率 | 1.574 |
| 储存条件 | 2-8°C，密封，干燥 |
Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 218457-67-1: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: tan Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 88 - 90 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C15H18N2O Molecular Weight: 242 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Oxidizing agents, acid chlorides. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 218457-67-1 unlisted. LD50/LC50: Not available. Carcinogenicity: 6-[4-(Tert-butyl)phenoxy]pyridin-3-amine - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 218457-67-1: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 218457-67-1 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 218457-67-1 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
| 危害码 (欧洲) | Xi: Irritant; |
|---|---|
| 海关编码 | 2933399090 |
| 海关编码 | 2933399090 |
|---|---|
| 中文概述 | 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |