182167-02-8

• 常用中文名：阿考比芬
• 常用英文名：Acolbifene
• CAS号：182167-02-8
• 分子式：C₂₉H₃₁NO₄
• 分子量：457.56
• 相关类别： 研究领域 癌症
• 发布时间：2016-07-14 10:48:11
• 更新时间：2024-01-09 11:59:12
• Acolbifene (EM652) 是第四代选择性的estrogen receptor拮抗剂,LC50 值为 22±3 nM。

名称

• 中文名: 阿考比芬
• 英文名: (2S)-3-(4-Hydroxyphenyl)-4-methyl-2-{4-[2-(1-piperidinyl)ethoxy]p henyl}-2H-chromen-7-ol hydrochloride (1:1)
• 英文别名: (S)-3-(4-carboxybenzyl)willardiine; (aS)-a-Amino-3-((4-carboxyphenyl)methyl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoicacid; (S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol; UBP 282

物化性质

• 沸点: 651.5ºC at 760mmHg
• 分子式: C₂₉H₃₁NO₄
• 分子量: 457.56
• 闪点: 347.8ºC
• PSA: 62.16000
• LogP: 6.76680
• 外观性状: 固体
• 储存条件: 2-8°C， 密封

生物活性

• 描述: Acolbifene (EM652) 是第四代选择性的estrogen receptor拮抗剂,LC50 值为 22±3 nM。
• 相关类别:
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 癌症
• 参考文献:

  [1]. Wang T, et al. Recent advances in selective estrogen receptor modulators for breast cancer. Mini Rev Med Chem. 2009 Sep;9(10):1191-201.

合成路线

17720-60-4 ~% 182167-02-8

文献：Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

156-38-7 ~% 182167-02-8

文献：Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

130064-21-0 ~% 182167-02-8

文献：Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

151533-32-3 ~% 182167-02-8

文献：Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

108-46-3 ~% 182167-02-8

文献：Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

151533-33-4 ~% 182167-02-8

文献：Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

151533-34-5 ~% 182167-02-8

文献：Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

上下游产品

上游产品  6
17720-60-4 156-38-7 130064-21-0 151533-32-3
108-46-3 151533-34-5
下游产品  0