Acolbifene

Modify Date: 2024-01-09 11:59:12

Acolbifene Structure
Acolbifene structure
Common Name Acolbifene
CAS Number 182167-02-8 Molecular Weight 457.56
Density N/A Boiling Point 651.5ºC at 760mmHg
Molecular Formula C29H31NO4 Melting Point N/A
MSDS N/A Flash Point 347.8ºC

 Use of Acolbifene


Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 22±3 nM.

 Names

Name (2S)-3-(4-Hydroxyphenyl)-4-methyl-2-{4-[2-(1-piperidinyl)ethoxy]p henyl}-2H-chromen-7-ol hydrochloride (1:1)
Synonym More Synonyms

 Acolbifene Biological Activity

Description Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 22±3 nM.
Related Catalog
References

[1]. Wang T, et al. Recent advances in selective estrogen receptor modulators for breast cancer. Mini Rev Med Chem. 2009 Sep;9(10):1191-201.

 Chemical & Physical Properties

Boiling Point 651.5ºC at 760mmHg
Molecular Formula C29H31NO4
Molecular Weight 457.56
Flash Point 347.8ºC
PSA 62.16000
LogP 6.76680

 Synthetic Route

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Acolbifene Structure

Acolbifene

CAS#:182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

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Acolbifene Structure

Acolbifene

CAS#:182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

~%

Acolbifene Structure

Acolbifene

CAS#:182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

~%

Acolbifene Structure

Acolbifene

CAS#:182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

~%

Acolbifene Structure

Acolbifene

CAS#:182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

~%

Acolbifene Structure

Acolbifene

CAS#:182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

~%

Acolbifene Structure

Acolbifene

CAS#:182167-02-8

Literature: Gauthier; Caron; Cloutier; Dory; Favre; Larouche; Mailhot; Ouellet; Schwerdtfeger; Leblanc; Martel; Simard; Merand; Belanger; Labrie Journal of Medicinal Chemistry, 1997 , vol. 40, # 14 p. 2117 - 2122

 Synonyms

(S)-3-(4-carboxybenzyl)willardiine
(aS)-a-Amino-3-((4-carboxyphenyl)methyl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoicacid
(S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol
UBP 282
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