14439-61-3

• 常用中文名：4'-氯地西泮
• 常用英文名：4'-Chlorodiazepam
• CAS号：14439-61-3
• 分子式：C₁₆H₁₂Cl₂N₂O
• 分子量：319.18500
• 发布时间：2018-12-31 15:31:29
• 更新时间：2025-08-23 22:10:02
• A potent, selective ligand for the mitochondrial translocator protein 18kDa (TSPO/PBR).

名称

• 中文名: 4'-氯地西泮
• 英文名: 4'-Chlorodiazepam
• 英文别名: Chlorodiazepam; 4'-Chlorodiazepam; 7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one; Ro-5-4864; 7-chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one

物化性质

• 密度: 1.35g/cm3
• 沸点: 517.1ºC at 760mmHg
• 熔点: 160-163ºC
• 分子式: C₁₆H₁₂Cl₂N₂O
• 分子量: 319.18500
• 闪点: 266.6ºC
• 精确质量: 318.03300
• PSA: 32.67000
• LogP: 3.30780
• 蒸汽压: 8.43E-11mmHg at 25°C
• 折射率: 1.647
• 储存条件: 2-8℃，干燥，密闭

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DF0500000 CHEMICAL NAME : 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl- CAS REGISTRY NUMBER : 14439-61-3 BEILSTEIN REFERENCE NO. : 0685202 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C16-H12-Cl2-N2-O MOLECULAR WEIGHT : 319.20 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 10 nmol/L REFERENCE : CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 49,115,1990

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): 22
• 危险品运输编码: UN 2811
• RTECS号: DF0500000
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2933990090

合成路线

99833-83-7 ~81% 14439-61-3

文献：Vejdelek; Polivka; Protiva Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1064 - 1069

99833-82-6 ~94% 14439-61-3

文献：Vejdelek; Polivka; Protiva Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1064 - 1069

5571-60-8 74-88-4 ~36% 14439-61-3

文献：Cortes, Eduardo Cortes; Martinez, Isidro Ebromares; Mellado, Olivia Garcia Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 6 p. 1189 - 1194

724-07-2 ~% 14439-61-3

文献：Vejdelek; Polivka; Protiva Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1064 - 1069

78961-59-8 ~% 14439-61-3

文献：Vejdelek; Polivka; Protiva Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1064 - 1069

100-00-5 ~% 14439-61-3

文献：Vejdelek; Polivka; Protiva Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1064 - 1069

140-53-4 ~% 14439-61-3

文献：Vejdelek; Polivka; Protiva Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1064 - 1069

上下游产品

上游产品  6
5571-60-8 74-88-4 724-07-2 78961-59-8
100-00-5 140-53-4
下游产品  0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%