95523-13-0

• 常用中文名：N-[(4-氨基苯基)甲基]腺苷
• 常用英文名：N-[(4-Aminophenyl)methyl]adenosine
• CAS号：95523-13-0
• 分子式：C₁₇H₂₀N₆O₄
• 分子量：372.38
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 腺苷受体
• 发布时间：2017-07-21 10:51:16
• 更新时间：2024-01-11 13:57:49
• N-[(4-Aminophenyl)methyl]adenosine是腺苷受体抑制剂,作用于大鼠ecto-5′-Nucleotidase, Ki 值为29 nM。

名称

• 中文名: N-[(4-氨基苯基)甲基]腺苷
• 英文名: N-(2,3-dihydroxypropyl)-N-(2-hydroxyethyl)nitrous amide
• 英文别名: 1,2-Propanediol,3-((2-hydroxyethyl)nitrosoamino); N-Nitroso-2,3-dihydroxypropyl-2-hydroxyethylamine; 3-[(2-hydroxyethyl)(nitroso)amino]propane-1,2-diol; N-Nitrosodihydroxypropylethanolamine; N-Nitroso-2,3-dihydroxypropylethanolamine; N6-(p-aminobenzyl)-adenosine; Ndpea; 3-((2-Hydroxyethyl)nitrosamino)-1,2-propanediol; 1,2-Propanediol,3-((2-hydroxyethyl)nitrosamino); N6-(4-amino-benzyl)-adenosine; [125I]-N6-(4-Aminobenzyl)adenosine; N-[(4-Aminophenyl)methyl]adenosine

物化性质

• 密度: 1.71g/cm3
• 沸点: 749ºC at 760mmHg
• 分子式: C₁₇H₂₀N₆O₄
• 分子量: 372.38
• 闪点: 406.8ºC
• PSA: 93.36000
• 折射率: 1.8
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: N-[(4-Aminophenyl)methyl]adenosine是腺苷受体抑制剂,作用于大鼠ecto-5′-Nucleotidase, Ki 值为29 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Bhattarai S, et al. α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58(15):6248-63.

  [2]. Chen JB, et al. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. 2011 Aug 1;6(8):1390-400.

  [3]. Zhu Z, et al. Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem. 2008 Apr 1;16(7):3848-65.

合成路线

40297-54-9 ~77% 95523-13-0

文献：Robins; Asakura; Kaneko; Shibuya; Jakobs; Agbanyo; Cass; Paterson Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1627 - 1646

2004-06-0 140401-57-6 ~% 95523-13-0

文献：INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES Patent: EP2511283 A1, 2012 ; Location in patent: Page/Page column 40 ;

112533-71-8 ~% 95523-13-0

文献：Linden; Patel; Earl; Craig; Daluge Journal of medicinal chemistry, 1988 , vol. 31, # 4 p. 745 - 751

100-11-8 ~% 95523-13-0

文献：Robins; Asakura; Kaneko; Shibuya; Jakobs; Agbanyo; Cass; Paterson Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1627 - 1646

58-61-7 ~% 95523-13-0

文献：Robins; Asakura; Kaneko; Shibuya; Jakobs; Agbanyo; Cass; Paterson Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1627 - 1646

556-18-3 ~% 95523-13-0

文献：INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES Patent: EP2511283 A1, 2012 ;

3419-18-9 ~% 95523-13-0

文献：INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES Patent: EP2511283 A1, 2012 ;