29400-42-8

• 常用中文名：煙麴黴酸
• 常用英文名：Helvolic acid
• CAS号：29400-42-8
• 分子式：C₃₃H₄₄O₈
• 分子量：568.69800
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-03-09 08:00:00
• 更新时间：2025-08-25 10:17:58
• Helvolic acid (Fumigacin) 是从真菌中得到的抗生素,有效作用于革兰氏阳性菌。

名称

• 中文名: 煙麴黴酸
• 英文名: helvolic acid
• 英文别名: hervolic acid; helvol acid; Helvolsaeure; Helvolic acid; Fumigacin; (2Z)-2-[(4S,5S,6S,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

物化性质

• 密度: 1.2g/cm3
• 沸点: 675.9ºC at 760 mmHg
• 分子式: C₃₃H₄₄O₈
• 分子量: 568.69800
• 闪点: 209ºC
• 精确质量: 568.30400
• PSA: 124.04000
• LogP: 5.40010
• 蒸汽压: 5.01E-20mmHg at 25°C
• 折射率: 1.556

生物活性

• 描述: Helvolic acid (Fumigacin) 是从真菌中得到的抗生素,有效作用于革兰氏阳性菌。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Ratnaweera PB, et al. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology. 2014 Mar;5(1):23-28. Epub 2014 Mar 25.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RC1370000 CHEMICAL NAME : 29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4-alpha, 6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-bet a)- CAS REGISTRY NUMBER : 29400-42-8 BEILSTEIN REFERENCE NO. : 3230584 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C33-H44-O8 MOLECULAR WEIGHT : 568.77 WISWESSER LINE NOTATION : L E5 B666 FY LV OV PUTJ A1 FUYVQ3UY1&1 GOV1 I1 J1 KOV1 N1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978

安全

• RTECS号: RC1370000