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Product Name: Helvolic acid
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29400-42-8

29400-42-8 structure

29400-42-8 structure

Name: Helvolic acid
Chemical Name: helvolic acid
CAS Number: 29400-42-8
Molecular Formula: C₃₃H₄₄O₈
Molecular Weight: 568.69800
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-03-09 08:00:00
Modify Date: 2024-01-16 12:09:42
Helvolic acid (Fumigacin) is an antibiotic isolated from Xylaria sp, active against the Gram-positive bacteria[1].

Name	helvolic acid
Synonyms	hervolic acid helvol acid Helvolsaeure Helvolic acid Fumigacin (2Z)-2-[(4S,5S,6S,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

Description	Helvolic acid (Fumigacin) is an antibiotic isolated from Xylaria sp, active against the Gram-positive bacteria[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Ratnaweera PB, et al. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology. 2014 Mar;5(1):23-28. Epub 2014 Mar 25.

Density	1.2g/cm3
Boiling Point	675.9ºC at 760 mmHg
Molecular Formula	C₃₃H₄₄O₈
Molecular Weight	568.69800
Flash Point	209ºC
Exact Mass	568.30400
PSA	124.04000
LogP	5.40010
Vapour Pressure	5.01E-20mmHg at 25°C
Index of Refraction	1.556

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC1370000

CHEMICAL NAME :: 29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4-alpha, 6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-bet a)-

CAS REGISTRY NUMBER :: 29400-42-8

BEILSTEIN REFERENCE NO. :: 3230584

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C33-H44-O8

MOLECULAR WEIGHT :: 568.77

WISWESSER LINE NOTATION :: L E5 B666 FY LV OV PUTJ A1 FUYVQ3UY1&1 GOV1 I1 J1 KOV1 N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978

RTECS	RC1370000