Helvolic acid

Modify Date: 2025-08-25 10:17:58

Helvolic acid Structure
Helvolic acid structure
Common Name Helvolic acid
CAS Number 29400-42-8 Molecular Weight 568.69800
Density 1.2g/cm3 Boiling Point 675.9ºC at 760 mmHg
Molecular Formula C33H44O8 Melting Point N/A
MSDS N/A Flash Point 209ºC

 Use of Helvolic acid


Helvolic acid (Fumigacin) is an antibiotic isolated from Xylaria sp, active against the Gram-positive bacteria[1].

 Names

Name helvolic acid
Synonym More Synonyms

 Helvolic acid Biological Activity

Description Helvolic acid (Fumigacin) is an antibiotic isolated from Xylaria sp, active against the Gram-positive bacteria[1].
Related Catalog
References

[1]. Ratnaweera PB, et al. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology. 2014 Mar;5(1):23-28. Epub 2014 Mar 25.

 Chemical & Physical Properties

Density 1.2g/cm3
Boiling Point 675.9ºC at 760 mmHg
Molecular Formula C33H44O8
Molecular Weight 568.69800
Flash Point 209ºC
Exact Mass 568.30400
PSA 124.04000
LogP 5.40010
Vapour Pressure 5.01E-20mmHg at 25°C
Index of Refraction 1.556

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC1370000
CHEMICAL NAME :
29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4-alpha, 6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-bet a)-
CAS REGISTRY NUMBER :
29400-42-8
BEILSTEIN REFERENCE NO. :
3230584
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C33-H44-O8
MOLECULAR WEIGHT :
568.77
WISWESSER LINE NOTATION :
L E5 B666 FY LV OV PUTJ A1 FUYVQ3UY1&1 GOV1 I1 J1 KOV1 N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978

 Safety Information

RTECS RC1370000

 Synonyms

hervolic acid
helvol acid
Helvolsaeure
Helvolic acid
Fumigacin
(2Z)-2-[(4S,5S,6S,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid
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