<Suppliers Price>

Helvolic acid

Names

[ CAS No. ]:
29400-42-8

[ Name ]:
Helvolic acid

[Synonym ]:
hervolic acid
helvol acid
Helvolsaeure
Helvolic acid
Fumigacin
(2Z)-2-[(4S,5S,6S,8S,9S,10R,13R,14S,16S)-6,16-diacetyloxy-4,8,10,14-tetramethyl-3,7-dioxo-5,6,9,11,12,13,15,16-octahydro-4H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

Biological Activity

[Description]:

Helvolic acid (Fumigacin) is an antibiotic isolated from Xylaria sp, active against the Gram-positive bacteria[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Ratnaweera PB, et al. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology. 2014 Mar;5(1):23-28. Epub 2014 Mar 25.

Chemical & Physical Properties

[ Density]:
1.2g/cm3

[ Boiling Point ]:
675.9ºC at 760 mmHg

[ Molecular Formula ]:
C33H44O8

[ Molecular Weight ]:
568.69800

[ Flash Point ]:
209ºC

[ Exact Mass ]:
568.30400

[ PSA ]:
124.04000

[ LogP ]:
5.40010

[ Vapour Pressure ]:
5.01E-20mmHg at 25°C

[ Index of Refraction ]:
1.556

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RC1370000
CHEMICAL NAME :
29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4-alpha, 6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-bet a)-
CAS REGISTRY NUMBER :
29400-42-8
BEILSTEIN REFERENCE NO. :
3230584
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C33-H44-O8
MOLECULAR WEIGHT :
568.77
WISWESSER LINE NOTATION :
L E5 B666 FY LV OV PUTJ A1 FUYVQ3UY1&1 GOV1 I1 J1 KOV1 N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978

Safety Information

[ RTECS ]:
RC1370000

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.