25990-37-8

• 常用中文名：印苦楝内酯
• 常用英文名：Nimbolide
• CAS号：25990-37-8
• 分子式：C₂₇H₃₀O₇
• 分子量：466.52
• 相关类别： 信号通路 细胞周期/DNA损伤 CDK
• 发布时间：2017-07-05 13:33:06
• 更新时间：2024-01-03 17:29:27
• Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB,Wnt,PI3K-Akt,MAPK 和 JAK-STAT 信号通路。

名称

• 中文名: Nimbolide
• 英文名: Nimbolide
• 英文别名: Methyl [8-(3-furyl)-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-yl]acetate; 2H,5H-Cyclopenta[d]naphtho[2,3-b:1,8-b'c']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester; (4S,4aS,8aS)-4-(tert-Butyl-dimethylsilyl)oxy-7,7-dimethoxy-4a-methyl-3,4,5,6,8,8a-hexahydro-2H-naphthalen-1-one; (4S,4aS,8aS)-4-(dimethyl-tert-butyl-silyl)oxy-7,7-dimethoxy-4a-methyl-decalin-1-one

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 608.6±55.0 °C at 760 mmHg
• 分子式: C₂₇H₃₀O₇
• 分子量: 466.52
• 闪点: 321.9±31.5 °C
• 精确质量: 466.199158
• PSA: 92.04000
• LogP: 2.66
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.597
• 储存条件: -20°C，干燥，密封

生物活性

• 描述: Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB,Wnt,PI3K-Akt,MAPK 和 JAK-STAT 信号通路。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> CDK
• 靶点:

  NF-κB

  CDK4

  CDK6

• 参考文献:

  [1]. Bodduluru LN, et al. Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. Toxicol In Vitro. 2014 Aug;28(5):1026-35.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GY2370000 CAS REGISTRY NUMBER : 25990-37-8 LAST UPDATED : 199106 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C27-H30-O7 MOLECULAR WEIGHT : 466.57 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 30,159,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 30,159,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 30,159,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 225 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 30,159,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 30,159,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 30,159,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 30,159,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : >500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 30,159,1986

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• RTECS号: GY2370000