印苦楝内酯

更新时间:2024-01-03 17:29:27

印苦楝内酯结构式
印苦楝内酯结构式
品牌特惠专场
常用名 印苦楝内酯 英文名 Nimbolide
CAS号 25990-37-8 分子量 466.52
密度 1.3±0.1 g/cm3 沸点 608.6±55.0 °C at 760 mmHg
分子式 C27H30O7 熔点 N/A
MSDS 中文版 美版 闪点 321.9±31.5 °C
符号 GHS07
GHS07
信号词 Warning

 印苦楝内酯用途


Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB,Wnt,PI3K-Akt,MAPK 和 JAK-STAT 信号通路。

 印苦楝内酯名称

中文名 Nimbolide
英文名 Nimbolide
英文别名 更多

 印苦楝内酯生物活性

描述 Nimbolide 是一种源自 Azadirachta indica L 叶和花的三萜化合物。Nimbolide 通过抑制 NF-κB 而诱导肿瘤细胞凋亡。 Nimbolide 抑制 CDK4/CDK6 激酶活性。Nimbolide 抑制 NF-κB,Wnt,PI3K-Akt,MAPK 和 JAK-STAT 信号通路。
相关类别
靶点

NF-κB

CDK4

CDK6

参考文献

[1]. Bodduluru LN, et al. Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms. Toxicol In Vitro. 2014 Aug;28(5):1026-35.

 印苦楝内酯物理化学性质

密度 1.3±0.1 g/cm3
沸点 608.6±55.0 °C at 760 mmHg
分子式 C27H30O7
分子量 466.52
闪点 321.9±31.5 °C
精确质量 466.199158
PSA 92.04000
LogP 2.66
蒸汽压 0.0±1.7 mmHg at 25°C
折射率 1.597
储存条件 -20°C,干燥,密封

 印苦楝内酯毒性和生态

 印苦楝内酯安全信息

符号 GHS07
GHS07
信号词 Warning
危害声明 H302
警示性声明 P301 + P312 + P330
危害码 (欧洲) Xi
危险品运输编码 NONH for all modes of transport
RTECS号 GY2370000

 印苦楝内酯文献4

更多文献
Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma.

Int. J. Mol. Sci. 16 , 23405-24, (2015)

Osteosarcoma (OS) is a primary malignant tumor of bone and is most prevalent in children and adolescents. OS is frequently associated with pulmonary metastasis, which is the main cause of OS-related m...

Nimbolide, a constituent of Azadirachta indica, inhibits Plasmodium falciparum in culture.

Southeast Asian J. Trop. Med. Public Health 16(1) , 66-72, (1985)

The terpenoid lactone nimbolide, the structure of which has been unambiguously established, was found to inhibit Plasmodium falciparum in culture with a moderate potency. The EC50 against the parasite...

Induction of cell cycle arrest, DNA damage, and apoptosis by nimbolide in human renal cell carcinoma cells.

Tumour Biol. 36(10) , 7539-47, (2015)

Nimbolide is a tetranortriterpenoid isolated from the leaves and flowers of Azadirachta indica which has been shown to exhibit anticancer, antioxidant, anti-inflammatory, and anti-invasive properties ...

 印苦楝内酯英文别名

Methyl [8-(3-furyl)-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-yl]acetate
2H,5H-Cyclopenta[d]naphtho[2,3-b:1,8-b'c']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester
(4S,4aS,8aS)-4-(tert-Butyl-dimethylsilyl)oxy-7,7-dimethoxy-4a-methyl-3,4,5,6,8,8a-hexahydro-2H-naphthalen-1-one
(4S,4aS,8aS)-4-(dimethyl-tert-butyl-silyl)oxy-7,7-dimethoxy-4a-methyl-decalin-1-one
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