1597-82-6

• 常用中文名：帕拉米松乙酸酯
• 常用英文名：Paramethasone Acetate
• CAS号：1597-82-6
• 分子式：C₂₄H₃₁FO₆
• 分子量：434.49800
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2018-08-21 14:44:34
• 更新时间：2024-01-04 22:47:24
• 醋酸参数沙松是一种合成糖皮质激素,具有抗炎和免疫抑制活性[1]。

名称

• 中文名: 帕拉米松乙酸酯
• 英文名: [2-[(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
• 中文别名: 酸醋帕拉米松
• 英文别名: PARAMETHASONE ACETATE; DSSTox_CID_3422; Paramethasone-21-acetate

物化性质

• 密度: 1.29 g/cm1.29 g/cm3
• 沸点: 584.2ºC at 760 mmHg
• 熔点: >148°C (dec.) (lit.)
• 分子式: C₂₄H₃₁FO₆
• 分子量: 434.49800
• 闪点: 307.1ºC
• 精确质量: 434.21000
• PSA: 100.90000
• LogP: 2.32240
• 外观性状: 白色至米白色固体
• 蒸汽压: 4.42E-16mmHg at 25°C
• 折射率: 1.569
• 储存条件: 2-8°C

生物活性

• 描述: 醋酸参数沙松是一种合成糖皮质激素,具有抗炎和免疫抑制活性[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU4025000 CHEMICAL NAME : Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,17,21-trihydroxy-16-alpha-meth yl-, 21-acetate CAS REGISTRY NUMBER : 1597-82-6 LAST UPDATED : 199710 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C24-H31-F-O6 MOLECULAR WEIGHT : 434.55 WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 CQ E1 FV1OV1 FQ G1 LF HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 392 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,588,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 10500 ug/kg SEX/DURATION : female 1-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : NFGZAD Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku, Toyko 162, Japan) V.1- 1956- Volume(issue)/page/year: 13,211,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 2625 ug/kg SEX/DURATION : female 1-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) REFERENCE : NFGZAD Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku, Toyko 162, Japan) V.1- 1956- Volume(issue)/page/year: 13,211,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1177 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 297 (estimated)

安全

• 危害码 (欧洲): Xn