CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TU4025000
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CHEMICAL NAME :
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Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,17,21-trihydroxy-16-alpha-meth yl-, 21-acetate
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CAS REGISTRY NUMBER :
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1597-82-6
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C24-H31-F-O6
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MOLECULAR WEIGHT :
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434.55
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WISWESSER LINE NOTATION :
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L E5 B666 OV AHTTT&J A1 CQ E1 FV1OV1 FQ G1 LF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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392 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>1 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,588,1982 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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DOSE :
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10500 ug/kg
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SEX/DURATION :
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female 1-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
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REFERENCE :
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NFGZAD Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku, Toyko 162, Japan) V.1- 1956- Volume(issue)/page/year: 13,211,1968
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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DOSE :
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2625 ug/kg
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SEX/DURATION :
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female 1-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
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REFERENCE :
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NFGZAD Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku, Toyko 162, Japan) V.1- 1956- Volume(issue)/page/year: 13,211,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1177 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 297 (estimated)
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