150915-40-5

• 常用中文名：盐酸替罗非班
• 常用英文名：Tirofiban hydrochloride
• CAS号：150915-40-5
• 分子式：C₂₂H₃₉ClN₂O₆S
• 分子量：495.073
• 相关类别： 原料药 循环系统用药 防治心绞痛药
• 发布时间：2018-02-21 08:00:00
• 更新时间：2024-01-02 09:12:15
• Tirofiban盐酸盐一水合物是非肽类,糖蛋白IIb/IIIa拮抗剂。

名称

• 中文名: 盐酸替罗非班
• 英文名: tirofiban hydrochloride
• 中文别名: 替罗非班盐酸盐水合物; N-(正丁基磺酰基)-O-[4-(4-哌啶基)丁基]-L-酪氨酸盐酸盐水合物; 盐酸替罗非班
• 英文别名: L 700462 MK 383 N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine; N-(butylsulfonyl)- O-[4-(4-piperidinyl)butyl]-L-tyrosine monohydrochloride monohydrate; N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]tyrosine hydrochloride hydrate; N-(Butylsulfonyl)-O-[4-(piperidin-4-yl)butyl]-L-tyrosine hydrochloride hydrate; (2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid,hydrate,hydrochloride; Tirofiban hydrochloride; Tirofiban hydrochloride monohydrate; tirofiban hydrochloride anhydrous; Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, hydrochloride, hydrate (1:1:1); Tirofiban Hydrochloride Hydrate; Tirofiban (hydrochloride monohydrate)

物化性质

• 沸点: 611.7ºC at 760 mmHg
• 熔点: 135-137ºC
• 分子式: C₂₂H₃₉ClN₂O₆S
• 分子量: 495.073
• 闪点: 323.7ºC
• 精确质量: 494.221741
• PSA: 122.34000
• LogP: 5.48870
• 外观性状: 白色固体
• 储存条件: -20°C Freezer
• 水溶解性: DMSO: >12mg/mL at warmed to 60°C

生物活性

• 描述: Tirofiban盐酸盐一水合物是非肽类,糖蛋白IIb/IIIa拮抗剂。
• 相关类别:
  信号通路 >> 细胞骨架 >> Integrin
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Winter JP, Juergens CP. The role of tirofiban in the management of coronary artery disease. Cardiovasc Hematol Disord Drug Targets. 2008 Jun;8(2):138-46.

  [2]. van 't Hof AW, Valgimigli M. Defining the role of platelet glycoprotein receptor inhibitors in STEMI: focus on tirofiban. Drugs. 2009;69(1):85-100.

  [3]. Valgimigli M, Biondi-Zoccai G, Tebaldi M et al. Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: a meta-analysis of randomized trials. Eur Heart J. 2010 Jan;31(1):35-49.

  [4]. Valgimigli M, Tebaldi M. Safety evaluation of tirofiban. Expert Opin Drug Saf. 2010 Sep;9(5):801-19.

  [5]. Diaz JF, Cardenal R, Gomez-Manchero A, Sanchez-Gonzalez C. Safety and efficacy of tirofiban as adjunctive therapy for patients with ST-elevation myocardial infarction: a comparison versus placebo and abciximab. Cardiovasc Hematol Agents Med Chem. 2011 Jul 1;9(3):147-53.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-37-45
• 危险品运输编码: NONH for all modes of transport