337962-93-3

• 常用中文名：UK-414495
• 常用英文名：UK-414495
• CAS号：337962-93-3
• 分子式：C₁₆H₂₅N₃O₃S
• 分子量：339.45
• 发布时间：2017-08-28 15:29:59
• 更新时间：2024-01-13 11:38:42
• (Rac)-UK-414495(实施例7)是一种有效的中性内肽酶(NEP)抑制剂。(Rac)-UK-414495引起女性性生殖器中cAMP的增强[1]。

名称

• 英文名: 2-[[1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl]pentanoic acid
• 英文别名: uk-414,495

物化性质

• 分子式: C₁₆H₂₅N₃O₃S
• 分子量: 339.45
• 精确质量: 339.16200
• PSA: 123.91000
• LogP: 4.13990

生物活性

• 描述: (Rac)-UK-414495(实施例7)是一种有效的中性内肽酶(NEP)抑制剂。(Rac)-UK-414495引起女性性生殖器中cAMP的增强[1]。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 代谢酶/蛋白酶 >> 脑啡肽酶
• 参考文献:

  [1]. Graham NM, et, al. NEP inhibitors for the treatment of female sexual dysfunction. EP1481667A1.

合成路线

388630-83-9 ~83% 337962-93-3

文献：Pryde, David C.; Cook, Andrew S.; Burring, Denise J.; Jones, Lyn H.; Foll, Stephanie; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Middleton, Donald S.; Foster, Laura; Barker, Laura; Van Der Graaf, Piet; Stacey, Peter; Kohl, Christopher; Coggon, Sara; Beaumont, Kevin Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 142 - 159

118783-85-0 ~% 337962-93-3

文献：Pryde, David C.; Maw, Graham N.; Planken, Simon; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Barber, Christopher G.; Russell, Rachel; Foster, Laura; Barker, Laura; Wayman, Christopher; Van Der Graaf, Piet; Stacey, Peter; Morren, Debbie; Kohl, Christopher; Beaumont, Kevin; Coggon, Sara; Tute, Michael Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4409 - 4424

3400-45-1 ~% 337962-93-3

文献：Pryde, David C.; Maw, Graham N.; Planken, Simon; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Barber, Christopher G.; Russell, Rachel; Foster, Laura; Barker, Laura; Wayman, Christopher; Van Der Graaf, Piet; Stacey, Peter; Morren, Debbie; Kohl, Christopher; Beaumont, Kevin; Coggon, Sara; Tute, Michael Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4409 - 4424

118756-03-9 ~% 337962-93-3

文献：Pryde, David C.; Maw, Graham N.; Planken, Simon; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Barber, Christopher G.; Russell, Rachel; Foster, Laura; Barker, Laura; Wayman, Christopher; Van Der Graaf, Piet; Stacey, Peter; Morren, Debbie; Kohl, Christopher; Beaumont, Kevin; Coggon, Sara; Tute, Michael Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4409 - 4424

337962-91-1 ~% 337962-93-3

文献：Pryde, David C.; Maw, Graham N.; Planken, Simon; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Barber, Christopher G.; Russell, Rachel; Foster, Laura; Barker, Laura; Wayman, Christopher; Van Der Graaf, Piet; Stacey, Peter; Morren, Debbie; Kohl, Christopher; Beaumont, Kevin; Coggon, Sara; Tute, Michael Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4409 - 4424

上下游产品

上游产品  5
388630-83-9 118783-85-0 3400-45-1 118756-03-9
337962-91-1
下游产品  0