Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder

…, S Foll, MY Platts, V Sanderson, M Corless…

文献索引：Pryde, David C.; Cook, Andrew S.; Burring, Denise J.; Jones, Lyn H.; Foll, Stephanie; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Middleton, Donald S.; Foster, Laura; Barker, Laura; Van Der Graaf, Piet; Stacey, Peter; Kohl, Christopher; Coggon, Sara; Beaumont, Kevin Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 142 - 159

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被引用次数: 11

摘要

A series of substituted glutaramides were synthesised using Candoxatrilat 1 as a lead and evaluated for potency against neutral endopeptidase (NEP) as a potential treatment for female sexual arousal disorder (FSAD). In this paper, we describe studies in which we were able to increase NEP activity substantially over the levels reported for previous compounds from this programme by appropriate substitution in both the P1′ and P2′ regions. ...