UK-414495

Modify Date: 2024-01-13 11:38:42

UK-414495 Structure
UK-414495 structure
Common Name UK-414495
CAS Number 337962-93-3 Molecular Weight 339.45
Density N/A Boiling Point N/A
Molecular Formula C16H25N3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of UK-414495


(Rac)-UK-414495 (example 7) is a potent neutral endopeptidase (NEP) inhibitor. (Rac)-UK-414495 causes potentiation of cAMP in the sexual genitalia of the female[1].

 Names

Name 2-[[1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl]methyl]pentanoic acid
Synonym More Synonyms

 UK-414495 Biological Activity

Description (Rac)-UK-414495 (example 7) is a potent neutral endopeptidase (NEP) inhibitor. (Rac)-UK-414495 causes potentiation of cAMP in the sexual genitalia of the female[1].
Related Catalog
References

[1]. Graham NM, et, al. NEP inhibitors for the treatment of female sexual dysfunction. EP1481667A1.

 Chemical & Physical Properties

Molecular Formula C16H25N3O3S
Molecular Weight 339.45
Exact Mass 339.16200
PSA 123.91000
LogP 4.13990

 Synthetic Route

~83%

UK-414495 Structure

UK-414495

CAS#:337962-93-3

Literature: Pryde, David C.; Cook, Andrew S.; Burring, Denise J.; Jones, Lyn H.; Foll, Stephanie; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Middleton, Donald S.; Foster, Laura; Barker, Laura; Van Der Graaf, Piet; Stacey, Peter; Kohl, Christopher; Coggon, Sara; Beaumont, Kevin Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 142 - 159

~%

UK-414495 Structure

UK-414495

CAS#:337962-93-3

Literature: Pryde, David C.; Maw, Graham N.; Planken, Simon; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Barber, Christopher G.; Russell, Rachel; Foster, Laura; Barker, Laura; Wayman, Christopher; Van Der Graaf, Piet; Stacey, Peter; Morren, Debbie; Kohl, Christopher; Beaumont, Kevin; Coggon, Sara; Tute, Michael Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4409 - 4424

~%

UK-414495 Structure

UK-414495

CAS#:337962-93-3

Literature: Pryde, David C.; Maw, Graham N.; Planken, Simon; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Barber, Christopher G.; Russell, Rachel; Foster, Laura; Barker, Laura; Wayman, Christopher; Van Der Graaf, Piet; Stacey, Peter; Morren, Debbie; Kohl, Christopher; Beaumont, Kevin; Coggon, Sara; Tute, Michael Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4409 - 4424

~%

UK-414495 Structure

UK-414495

CAS#:337962-93-3

Literature: Pryde, David C.; Maw, Graham N.; Planken, Simon; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Barber, Christopher G.; Russell, Rachel; Foster, Laura; Barker, Laura; Wayman, Christopher; Van Der Graaf, Piet; Stacey, Peter; Morren, Debbie; Kohl, Christopher; Beaumont, Kevin; Coggon, Sara; Tute, Michael Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4409 - 4424

~%

UK-414495 Structure

UK-414495

CAS#:337962-93-3

Literature: Pryde, David C.; Maw, Graham N.; Planken, Simon; Platts, Michelle Y.; Sanderson, Vivienne; Corless, Martin; Stobie, Alan; Barber, Christopher G.; Russell, Rachel; Foster, Laura; Barker, Laura; Wayman, Christopher; Van Der Graaf, Piet; Stacey, Peter; Morren, Debbie; Kohl, Christopher; Beaumont, Kevin; Coggon, Sara; Tute, Michael Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4409 - 4424

 Synonyms

uk-414,495
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