70497-14-2

• 常用中文名：鞘丝藻毒素 a
• 常用英文名：Teleocidin A1
• CAS号：70497-14-2
• 分子式：C₂₇H₃₉N₃O₂
• 分子量：437.61700
• 相关类别： 信号通路 表观遗传学 PKC
• 发布时间：2018-04-17 08:00:00
• 更新时间：2025-09-10 12:35:18
• Teleocidin A1(Lyngbytoxin A)是一种剧毒皮肤刺激物,是蛋白激酶C(PKC)的有效激活剂。Teleocidin A1对HeLa癌细胞具有抗增殖活性(IC50=9.2nm)[1][2]。

名称

• 中文名: 鞘丝藻毒素 a
• 英文名: lyngbyatoxin a
• 英文别名: lyngbyatoxin; 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,9-(1-ethenyl-1,5-dimethyl-4-hexenyl)-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl); (2S,5S)-9-[(R)-1-Ethenyl-1,5-dimethyl-4-hexenyl]-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one; 3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-9-(1-etheny; teleocidina; Teleocicin A-1; lyngbyatoxin A (teleocidin A-1); 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-9-(1-ethenyl-1,5-dimethyl-4-hexenyl)-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl); 5-dimethyl-4-hexenyl)-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-l; teleocidin A1

物化性质

• 密度: 1.06 g/cm3
• 沸点: 665.1ºC at 760 mmHg
• 分子式: C₂₇H₃₉N₃O₂
• 分子量: 437.61700
• 闪点: 356ºC
• 精确质量: 437.30400
• PSA: 68.36000
• LogP: 5.24580

生物活性

• 描述: Teleocidin A1(Lyngbytoxin A)是一种剧毒皮肤刺激物,是蛋白激酶C(PKC)的有效激活剂。Teleocidin A1对HeLa癌细胞具有抗增殖活性(IC50=9.2nm)[1][2]。
• 相关类别:
  信号通路 >> 表观遗传学 >> PKC
  研究领域 >> 癌症
  信号通路 >> TGF-beta/Smad 信号通路 >> PKC
• 参考文献:

  [1]. Stafford RG, et al. Comparison of the partition coefficient and skin penetration of a marine algal toxin (lyngbyatoxin A). Food Chem Toxicol. 1992;30(9):795-801.

  [2]. Youssef DT, Shaala LA, Mohamed GA, et al. 2,3-seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens. Nat Prod Res. 2015;29(8):703-709.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WY1981000 CHEMICAL NAME : 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-9-(1-ethenyl-1,5- dimethyl-4-hexenyl)-5-(hydroxymethyl)-1-methyl-2-(1-m ethylethyl)- CAS REGISTRY NUMBER : 70497-14-2 LAST UPDATED : 199012 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C27-H39-N3-O2 MOLECULAR WEIGHT : 437.69 WISWESSER LINE NOTATION : T569 1A O DM JN LVM&&TJ FX1&1U1&3UY1&1 J1 KY1&1 N1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,636,1967 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 204,193,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 26,660,1962