985-12-6

• 常用中文名：盐酸屈他维林
• 常用英文名：Drotaverine hydrochloride
• CAS号：985-12-6
• 分子式：C₂₄H₃₂ClNO₄
• 分子量：433.968
• 相关类别： 原料药 消化系统用药 胃肠解痉药
• 发布时间：2018-05-05 08:00:00
• 更新时间：2024-01-04 11:08:23
• 屈他维林(盐酸)是一种4型环核苷酸磷酸二酯酶(PDE4)抑制剂和一种L型电压依赖性钙通道(L-VDCC)阻滞剂,可阻止3',5'-环磷酸腺苷的降解。屈他维林(盐酸)在体内具有解痉功效,无抗胆碱能作用。

名称

• 中文名: 盐酸屈他维林
• 英文名: (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline,hydrochloride
• 中文别名: 盐酸屈维林
• 英文别名: 6,7,3',4'-Tetraethoxy-1-benzal-1,2,3,4-tetrahydroisoquinoline hydrochloride; DROTAVERINE HCL; DROTAVERINE HYDROCHLORIDE; Drotaverine HCl ;1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy 1,2,3,4-tetrahydroisoquinoline HCL; Drotaverinium chloride; Isodihydroperparine hydrochloride; MFCD01754602; Drotaverin hydrochloride; Isoquinoline, 1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-, (1Z)-, hydrochloride (1:1); (1Z)-1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; (1Z)-1-[(3,4-Diethoxyphenyl)methyliden]-6,7-diethoxy-1,2,3,4-tetrahydroisochinolinhydrochlorid; Tetraspasmin-Lefa; (1Z)-1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1); No-Spa hydrochloride

物化性质

• 密度: 1.097 g/cm3
• 沸点: 564ºC at 760 mmHg
• 熔点: 208-212ºC
• 分子式: C₂₄H₃₂ClNO₄
• 分子量: 433.968
• 闪点: 240.7ºC
• 精确质量: 433.201996
• PSA: 48.95000
• LogP: 6.05600
• 外观性状: 灰白-黄色结晶固体
• 储存条件: -20°C Freezer

生物活性

• 描述: 屈他维林(盐酸)是一种4型环核苷酸磷酸二酯酶(PDE4)抑制剂和一种L型电压依赖性钙通道(L-VDCC)阻滞剂,可阻止3',5'-环磷酸腺苷的降解。屈他维林(盐酸)在体内具有解痉功效,无抗胆碱能作用。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
• 参考文献:

  [1]. Patai Z, Guttman A, Mikus EG. Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine. Pharmacology. 2018;101(3-4):163-169.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NX5014000 CHEMICAL NAME : Isoquinoline, 1,2,3,4-tetrahydro-6,7-diethoxy-1-((3,4-diethoxypheny l)methylene)-, hydrochloride CAS REGISTRY NUMBER : 985-12-6 LAST UPDATED : 199606 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C24-H31-N-O4.Cl-H MOLECULAR WEIGHT : 434.02 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

安全

• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%