Drotaverine hydrochloride

Modify Date: 2024-01-04 11:08:23

Drotaverine hydrochloride structure	Common Name	Drotaverine hydrochloride
	CAS Number	985-12-6	Molecular Weight	433.968
	Density	1.097 g/cm3	Boiling Point	564ºC at 760 mmHg
	Molecular Formula	C₂₄H₃₂ClNO₄	Melting Point	208-212ºC
	MSDS	N/A	Flash Point	240.7ºC

Use of Drotaverine hydrochloride

Drotaverine (hydrochloride) is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.

Name	(1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline,hydrochloride
Synonym	More Synonyms

Description	Drotaverine (hydrochloride) is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
References	[1]. Patai Z, Guttman A, Mikus EG. Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine. Pharmacology. 2018;101(3-4):163-169.

Density	1.097 g/cm3
Boiling Point	564ºC at 760 mmHg
Melting Point	208-212ºC
Molecular Formula	C₂₄H₃₂ClNO₄
Molecular Weight	433.968
Flash Point	240.7ºC
Exact Mass	433.201996
PSA	48.95000
LogP	6.05600
Storage condition	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX5014000

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-6,7-diethoxy-1-((3,4-diethoxypheny l)methylene)-, hydrochloride

CAS REGISTRY NUMBER :: 985-12-6

LAST UPDATED :: 199606

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C24-H31-N-O4.Cl-H

MOLECULAR WEIGHT :: 434.02

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6,7,3',4'-Tetraethoxy-1-benzal-1,2,3,4-tetrahydroisoquinoline hydrochloride

DROTAVERINE HCL

DROTAVERINE HYDROCHLORIDE

Drotaverine HCl ;1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy 1,2,3,4-tetrahydroisoquinoline HCL

Drotaverinium chloride

Isodihydroperparine hydrochloride

MFCD01754602

Drotaverin hydrochloride

Isoquinoline, 1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-, (1Z)-, hydrochloride (1:1)

(1Z)-1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

(1Z)-1-[(3,4-Diethoxyphenyl)methyliden]-6,7-diethoxy-1,2,3,4-tetrahydroisochinolinhydrochlorid

Tetraspasmin-Lefa

(1Z)-1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1)

No-Spa hydrochloride

DC Chemicals Limited
China
Product Name: Drotaverine hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Drotaverine hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Drotaverine hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline,hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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