119719-11-8

• 常用中文名：伊拉曲肽
• 常用英文名：SDZ CO 611
• CAS号：119719-11-8
• 分子式：C₆₁H₈₆N₁₀O₂₀S₂
• 分子量：1343.521
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 生长抑素受体
• 发布时间：2021-09-11 15:21:16
• 更新时间：2024-01-02 19:04:44
• Ilatreotide (SDZ CO61) 是糖化生长抑素衍生物,是一种高效的生长抑素糖化类似物,具有改善的口服活性。Ilatreotide 可以抑制几种胃肠道和胰腺激素的空腹水平和餐后释放。Ilatreotide 可用于胃肠胰腺肿瘤的研究。

名称

• 中文名: 伊拉曲肽
• 英文名: Ilatreotide
• 英文别名: β-D-fructopyranose, 1-[[(1R)-2-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-7-[(1R)-1-hydroxyethyl]-4-[[[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]amino]carbonyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-16-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-19-yl]amino]-2-oxo-1-(phenylmethyl)ethyl]amino]-1-deoxy-4-O-α-D-glucopyranosyl-; β-D-Fructopyranose, 1-[[(1R)-2-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-7-[(1R)-1-hydroxyethyl]-4-[[[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]amino]carbonyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15, 18-pentaoxo-16-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-19-yl]amino]-2-oxo-1-(phenylmethyl)ethyl]amino]-1-deoxy-4-O-α-D-glucopyranosyl-; Ilatreotide; (4R,7S,10S,13R,16S,19R)-10-(4-Aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxy-2-butanyl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-{[(2R)-3-phenyl-2-({[(2R,3S,4R,5R)-2,3,5-trihydroxy-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]methyl}amino)propanoyl]amino}-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 1665.9±65.0 °C at 760 mmHg
• 分子式: C₆₁H₈₆N₁₀O₂₀S₂
• 分子量: 1343.521
• 闪点: 961.3±34.3 °C
• 精确质量: 1342.546143
• LogP: -1.41
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.693

生物活性

• 描述: Ilatreotide (SDZ CO61) 是糖化生长抑素衍生物,是一种高效的生长抑素糖化类似物,具有改善的口服活性。Ilatreotide 可以抑制几种胃肠道和胰腺激素的空腹水平和餐后释放。Ilatreotide 可用于胃肠胰腺肿瘤的研究。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 生长抑素受体
• 参考文献:

  [1]. Drum, et al. Use of somatostatin analogs in myocardial perfusion imaging. Patent. WO2008143958 A1.

  [2]. Albert R,et al. SDZ CO 611: a highly potent glycated analog of somatostatin with improved oral activity. Life Sci. 1993;53(6):517-25.

  [3]. Nelson-Piercy C, et al. Effect of a new oral somatostatin analog (SDZ CO 611) on gastric emptying, mouth to cecum transit time, and pancreatic and gut hormone release in normal male subjects. J Clin Endocrinol Metab. 1994 Feb;78(2):329-36.