119719-11-8

119719-11-8 structure

Name: SDZ CO 611
Chemical Name: Ilatreotide
CAS Number: 119719-11-8
Molecular Formula: C₆₁H₈₆N₁₀O₂₀S₂
Molecular Weight: 1343.521
Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
Create Date: 2021-09-11 15:21:16
Modify Date: 2024-01-02 19:04:44
Ilatreotide (SDZ CO61), glycated somatostatin derivative, is a highly potent glycated analog of somatostatin with improved oral activity. Ilatreotide can suppress the fasting level and postprandial release of several gastrointestinal and pancreatic hormones. Ilatreotide can be used for the research of gastroenteropancreatic tumors[1][2][3].

Name	Ilatreotide
Synonyms	β-D-fructopyranose, 1-[[(1R)-2-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-7-[(1R)-1-hydroxyethyl]-4-[[[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]amino]carbonyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-16-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-19-yl]amino]-2-oxo-1-(phenylmethyl)ethyl]amino]-1-deoxy-4-O-α-D-glucopyranosyl- β-D-Fructopyranose, 1-[[(1R)-2-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-7-[(1R)-1-hydroxyethyl]-4-[[[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]amino]carbonyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15, 18-pentaoxo-16-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-19-yl]amino]-2-oxo-1-(phenylmethyl)ethyl]amino]-1-deoxy-4-O-α-D-glucopyranosyl- Ilatreotide (4R,7S,10S,13R,16S,19R)-10-(4-Aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxy-2-butanyl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-{[(2R)-3-phenyl-2-({[(2R,3S,4R,5R)-2,3,5-trihydroxy-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]methyl}amino)propanoyl]amino}-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide

Description	Ilatreotide (SDZ CO61), glycated somatostatin derivative, is a highly potent glycated analog of somatostatin with improved oral activity. Ilatreotide can suppress the fasting level and postprandial release of several gastrointestinal and pancreatic hormones. Ilatreotide can be used for the research of gastroenteropancreatic tumors[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor
References	[1]. Drum, et al. Use of somatostatin analogs in myocardial perfusion imaging. Patent. WO2008143958 A1. [2]. Albert R,et al. SDZ CO 611: a highly potent glycated analog of somatostatin with improved oral activity. Life Sci. 1993;53(6):517-25. [3]. Nelson-Piercy C, et al. Effect of a new oral somatostatin analog (SDZ CO 611) on gastric emptying, mouth to cecum transit time, and pancreatic and gut hormone release in normal male subjects. J Clin Endocrinol Metab. 1994 Feb;78(2):329-36.