| 英文名 | (2-{[(3r,5r,6s)-1-[(1s)-2-(Tert-Butylsulfonyl)-1-Cyclopropylethyl]-6-(4-Chloro-3-Fluorophenyl)-5-(3-Chlorophenyl)-3-Methyl-2-Oxopiperidin-3-Yl]methyl}-1,3-Thiazol-5-Yl)acetic Acid |
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| 英文别名 |
(2-{[(3R,5R,6S)-6-(4-Chloro-3-fluorophenyl)-5-(3-chlorophenyl)-1-{(1S)-1-cyclopropyl-2-[(2-methyl-2-propanyl)sulfonyl]ethyl}-3-methyl-2-oxo-3-piperidinyl]methyl}-1,3-thiazol-5-yl)acetic acid
(2-{[(3r,5r,6s)-1-[(1s)-2-(Tert-Butylsulfonyl)-1-Cyclopropylethyl]-6-(4-Chloro-3-Fluorophenyl)-5-(3-Chlorophenyl)-3-Methyl-2-Oxopiperidin-3-Yl]methyl}-1,3-Thiazol-5-Yl)acetic Acid 5-Thiazoleacetic acid, 2-[[(3R,5R,6S)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-[(1,1-dimethylethyl)sulfonyl]ethyl]-3-methyl-2-oxo-3-piperidinyl]methyl]- |
| 描述 | 一种有效的MDM2-p53相互作用抑制剂,具有显着的生化(HTRF IC50=0.1 nM),细胞效力(SJSA-1 EdU IC50=16 nM)和有利的药代动力学特性；在SJSA-1骨肉瘤异种移植模型中显示出优异的抗肿瘤活性。ED50为11毫克/千克。 |
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| 参考文献 | References 1. Gonzalez AZ, et al. J Med Chem. 2014 Apr 10;57(7):2963-88. View Related Products by Target MDM2-p53 |
| 密度 | 1.4±0.1 g/cm3 |
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| 沸点 | 821.7±65.0 °C at 760 mmHg |
| 分子式 | C33H37Cl2FN2O5S2 |
| 分子量 | 695.692 |
| 闪点 | 450.8±34.3 °C |
| 精确质量 | 694.150513 |
| LogP | 6.72 |
| 蒸汽压 | 0.0±3.1 mmHg at 25°C |
| 折射率 | 1.611 |
