364590-63-6

364590-63-6结构式

常用中文名：3-氯-N-[4-(甲基氨基)环己基]-N-[[3-(4-吡啶基)苯基]甲基]-苯并[B]噻吩-2-甲酰胺
常用英文名：Smoothened Agonist, HCl
CAS号：364590-63-6
分子式：C₂₈H₂₈ClN₃OS
分子量：490.06
相关类别：信号通路干细胞及 Wnt 通路 SMO
发布时间：2017-05-22 02:29:59
更新时间：2026-07-01 18:18:28
(Rac)-SAG 是 SAG (HY-12848) 的异构体。SAG 是一种有效的 Smoothened (Smo) 受体激动剂 (EC50=3 nM; Kd=59 nM)。SAG 可激活 Hedgehog 信号通路并抵消 Cyclopamine (HY-17024) 对 Smo 的抑制作用。

中文名	3-氯-N-[4-(甲基氨基)环己基]-N-[[3-(4-吡啶基)苯基]甲基]-苯并[B]噻吩-2-甲酰胺
英文名	3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide,hydrate,dihydrochloride
中文别名	化合物 (Rac)-SAG
英文别名	3-Chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-cboxamide SAG . dihydrochloride (water soluble) 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-cboxamide,hydrate,dihydrochloride Smoothened Agonist,HCl (Rac)-SAG Benzo[b]thiophene-2-cboxamide, 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl] Hh-Ag 1.3 Frizzled6 agonist SAG1.3

描述	(Rac)-SAG 是 SAG (HY-12848) 的异构体。SAG 是一种有效的 Smoothened (Smo) 受体激动剂 (EC50=3 nM; Kd=59 nM)。SAG 可激活 Hedgehog 信号通路并抵消 Cyclopamine (HY-17024) 对 Smo 的抑制作用。
相关类别	信号通路 >> 干细胞及 Wnt 通路 >> SMO 研究领域 >> 癌症
靶点	EC50: 3 nM (Smo)[1]
参考文献	[1]. Guerrini G, et, al. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018 Dec; 233(12): 9799-9811. [2]. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6. [3]. Stanton BZ, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6. [4]. Lee S, et al. Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg. 2017 Feb 13 [5]. Fish EW, et al. Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Birth Defects Res A Clin Mol Teratol. 2016 Nov 1