Smoothened Agonist, HCl

Modify Date: 2025-08-27 08:41:36

Smoothened Agonist, HCl structure	Common Name	Smoothened Agonist, HCl
	CAS Number	364590-63-6	Molecular Weight	490.06
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₈ClN₃OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Smoothened Agonist, HCl

(Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3].

Name	3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide,hydrate,dihydrochloride
Synonym	More Synonyms

Description	(Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer
Target	EC50: 3 nM (Smo)[1]
References	[1]. Guerrini G, et, al. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018 Dec; 233(12): 9799-9811. [2]. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6. [3]. Stanton BZ, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6. [4]. Lee S, et al. Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg. 2017 Feb 13 [5]. Fish EW, et al. Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Birth Defects Res A Clin Mol Teratol. 2016 Nov 1

Molecular Formula	C₂₈H₂₈ClN₃OS
Molecular Weight	490.06
Exact Mass	579.12800
PSA	82.70000
LogP	8.72030
InChIKey	IYXUQUYRWPGIQL-UHFFFAOYSA-N
SMILES	CNC1CCC(N(Cc2cccc(-c3ccncc3)c2)C(=O)c2sc3ccccc3c2Cl)CC1.Cl.Cl.O

Smoothened Agonist,HCl

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Smoothened Agonist, HCl

Use of Smoothened Agonist, HCl

Names

Smoothened Agonist, HCl Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.