179411-93-9

• 常用中文名：SDZ 220-581盐酸盐
• 常用英文名：SDZ 220-581 (hydrochloride)
• CAS号：179411-93-9
• 分子式：C₁₆H₁₈Cl₂NO₅P
• 分子量：406.2
• 相关类别： 信号通路 跨膜转运 iGluR
• 发布时间：2018-11-30 19:33:56
• 更新时间：2025-08-25 17:48:48
• SDZ 220-581盐酸盐是高活性NMDA受体竞争性抑制剂,pKi为7.7。

名称

• 中文名: (S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐
• 英文名: SDZ 220-581 hydrochloride
• 英文别名: MFCD28053516; SDZ 220-581 (hydrochloride)

物化性质

• 分子式: C₁₆H₁₈Cl₂NO₅P
• 分子量: 406.2
• 精确质量: 405.029968
• 储存条件: room temp

生物活性

• 描述: SDZ 220-581盐酸盐是高活性NMDA受体竞争性抑制剂,pKi为7.7。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Gilmour G, et al. In vitro characterisation of the novel positive allosteric modulators of the mGlu? receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39.

  [2]. Linderholm K, et al. Role of the NMDA-receptor in Prepulse Inhibition in the Rat. Int J Tryptophan Res. 2010;3:1-12.

  [3]. Urwyler S, et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Neuropharmacology. 1996 Jun;35(6):655-69.

  [4]. Bakshi VP, et al. Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats. J Pharmacol Exp Ther. 1999 Feb;288(2):643-52.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport