毒理学数据:
1.急性毒性 LD50:1500mg/kg(大鼠经口)
2.刺激性 暂无资料
3.亚急性与慢性毒性 兔吸入含20%四氯苯(浓度为4~5g/m3或8~10g/m3)粉末1~17天,导致红细胞和血红蛋白降低,淋巴细胞增高。以0.005mg/kg饲喂大鼠,条件反射活动改变,血清中巯基含量降低,肝功能轻度失调。
生态学数据:
1.生态毒性
LC50:4.35mg/L(48h),1.55mg/L(96h)(蓝鳃太阳鱼);26.4mg/L(48h)(青鳉)
2.生物降解性
好氧生物降解(h):672~4320
厌氧生物降解(h):2880~17280
3.非生物降解性
空气中光氧化半衰期(h):763.1~7631
一级水解半衰期(h):>879a
4.生物富集性
BCF:2720~4830(鲤鱼,接触浓度10ppb,接触时间8周);1650~3930(鲤鱼,接触浓度1ppb,接触时间8周)
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DB9450000
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CHEMICAL NAME :
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Benzene, 1,2,4,5-tetrachloro-
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CAS REGISTRY NUMBER :
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95-94-3
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BEILSTEIN REFERENCE NO. :
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1618315
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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19
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MOLECULAR FORMULA :
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C6-H2-Cl4
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MOLECULAR WEIGHT :
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215.88
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WISWESSER LINE NOTATION :
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GR BG DG EG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1500 mg/kg
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
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REFERENCE :
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HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 30(1-3),8,1965
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1035 mg/kg
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
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REFERENCE :
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HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 30(1-3),8,1965
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>500 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 4,107,1952
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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1500 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness
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REFERENCE :
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GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 30(1),9,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5460 mg/kg/13W-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Blood - pigmented or nucleated red blood cells
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REFERENCE :
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-185330
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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896 mg/kg/28D-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
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REFERENCE :
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JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 11,663,1983
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2700 mg/kg/90D-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
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REFERENCE :
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DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 7,113,1984
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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4567 mg/kg/9W-I
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TOXIC EFFECTS :
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Endocrine - changes in adrenal weight Blood - changes in bone marrow (not otherwise specified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
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REFERENCE :
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GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 30(1),9,1965
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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12 mg/kg/35W-I
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TOXIC EFFECTS :
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Behavioral - alteration of classical conditioning Liver - changes in liver weight
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REFERENCE :
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GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 30(1),9,1965
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2100 mg/kg/14D-C
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Related to Chronic Data - death
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3126
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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4550 mg/kg/13W-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Blood - microcytosis with or without anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
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REFERENCE :
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NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3126
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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12 mg/kg/35W-I
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TOXIC EFFECTS :
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Blood - pigmented or nucleated red blood cells Blood - changes in other cell count (unspecified)
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REFERENCE :
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GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 30(1),9,1965
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