118-74-1

118-74-1结构式
118-74-1结构式
  • 常用中文名:六氯苯
  • 常用英文名:Hexachlorobenzene
  • CAS号:118-74-1
  • 分子式:C6Cl6
  • 分子量:284.782
  • 相关类别: 有机原料 烃类化合物及其衍生物 烃类卤化物
  • 发布时间:2018-02-07 08:00:00
  • 更新时间:2024-01-04 22:55:12
  • 用途一:用作拌种杀菌剂,可防治小麦腥黑穗病和杆黑穗病,还可用作焰火着色剂及生产五氯酚及五氯酚钠的原料
    用途二:有机元素微量分析时用做氯的标准,也用于有机合成
    用途三:用作拌种杀菌剂,可防治小麦腥黑穗病和杆黑穗病。用于生产花炮,作焰火色剂。还用作五氯酚及五氯酚钠的原料。
    用途四:有机微量分析测定高含量氯的标准。有机合成。杀虫剂。用作拌种杀菌剂,可防治小麦腥黑穗病和杆黑穗病。用于生产花炮,作焰火色剂。还用作五氯酚及五氯酚钠的原料。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。校准仪器和装置;评价方法;工作标准;质量保证/质量控制。
     

化源商城直购

中文名 六氯苯
英文名 hexachlorobenzene
中文别名 六氯代苯
全氯代苯
灭黑穗药
六氯苯13C6
六氯苯(HCB)
气相色谱/质谱联用仪校准用
过氯苯
英文别名 perchlorobenzene
HCB
EINECS 204-273-9
Hexachlorobenzene
Hexachlorobenzene 13C6
Hexachlorobenzene solution
MFCD00000540
密度 1.8±0.1 g/cm3
沸点 324.5±0.0 °C at 760 mmHg
熔点 227-229 °C(lit.)
分子式 C6Cl6
分子量 284.782
闪点 151.1±23.9 °C
精确质量 281.813110
LogP 4.89
外观性状 白色粉末
蒸汽压 0.0±0.6 mmHg at 25°C
折射率 1.607
储存条件

储存注意事项 储存于阴凉、通风的库房。远离火种、热源。包装密封。应与氧化剂、食用化学品分开存放,切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。

稳定性

1.稳定性 稳定

2.禁配物 强氧化剂

3.避免接触的条件 受热

4.聚合危害 不聚合

5.分解产物 氯化氢

分子结构

1、摩尔折射率:55.62

2、摩尔体积(cm3/mol):161.1

3、等张比容(90.2K):422.4

4、表面张力(dyne/cm):47.2

5、极化率(10-24cm3):22.05

计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:0

3.氢键受体数量:0

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:12

8.表面电荷:0

9.复杂度:104

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

更多

1.性状:纯品为无色细针状或小片状晶体,工业品为淡黄色或淡棕色晶体。

2.熔点(℃):229~231

3.沸点(℃):323~326(升华)

4.相对密度(水=1):2.044

5.相对蒸气密度(空气=1):9.8

6.饱和蒸气压(kPa):0.13(114.4℃)

7.临界压力(MPa):2.85

8.辛醇/水分配系数:5.73

9.闪点(℃):242

10.溶解性:不溶于水,溶于乙醚、氯仿、苯等多数有机溶剂。

11.溶度参数(J·cm-3)0.5:20.395

12.van der Waals面积(cm2·mol-1):1.272×1010

13.van der Waals体积(cm3·mol-1):106.700

14.晶相标准声称热(焓)( kJ·mol-1):-127.6

15.晶相标准熵(J·mol-1·K-1) :260.24

16.晶相标准生成自由能( kJ·mol-1):4.4

17.气相标准生成自由能( kJ·mol-1):44.1

18.气相标准热熔(J·mol-1·K-1):175.2

19.气相标准声称热(焓)( kJ·mol-1) :-35.5

20.气相标准熵(J·mol-1·K-1) :436.73

国标编号: 61876
CAS: 118-74-1
中文名称: 六氯苯
英文名称: Hexachlorobenzene;Hexachlorbenzd
别 名: 灭黑穗药
分子式: C6Cl6
分子量: 284.78
熔 点: 226℃ 沸点:323~326
密 度: 相对密度(水=1)2.44;
蒸汽压: 242℃
溶解性: 不溶于水,溶于乙醚、氯仿等多数有机溶剂
稳定性: 稳定
外观与性状: 纯品为无色细针状或小片状晶体,工业品为淡黄色或淡棕色晶体
危险标记: 14(有毒品)
用 途: 用作防治麦类黑穗病,种子和土壤消毒

2.对环境的影响:
一、健康危害

侵入途径:吸入、食入。
健康危害:中毒时能影响肝脏、中枢神经系统和心血管系统。用本品拌种时引起眼刺激、烧灼感、口鼻发干、疲乏、头痛、恶心等。可致皮肤溃疡。接触者尿和粪中有大量紫质排出。
二、毒理学资料及环境行为

急性毒性:LD 503500mg/kg(大鼠经口);4000mg/kg(小鼠经口)
亚急性和慢性毒性:动物亚急性和慢性毒性反应有神经毒性症状,肝、肾重量增加,尿中粪卟啉排泄增加等。
致突变性:DNA损伤:鼠伤寒沙门氏菌20umol/L。微粒体致突变:制酒酵母菌100ppm。
生殖毒性:大鼠经口最低中毒剂量(TDL 0):40mg/kg(孕后10~13天用药),对胎鼠肌肉、骨骼系统有影响。小鼠经口最低中毒剂量(TDL 0):1g/kg,有胚胎毒性,对泌尿生殖系统有影响。
致癌性:IARC致癌性评论:人为可疑性反应,动物为阳性反应。
危险特性:不易燃烧。受高热分解产生有毒腐蚀性烟气。
燃烧(分解)产物:一氧化碳、二氧化碳、氯化氢。

3.现场应急监测方法:


 

4.实验室监测方法:


气相色谱法《水和废水监测分析方法》(第三版)国家环保局编
气相色谱法《固体废弃物试验分析评价手册》中国环境监测总站等译

5.环境标准:

前苏联 车间空气中有害物质的最高容许浓度 0.9mg/m3
前苏联(1977) 居民区大气中有害物最大允许浓度 0.03mg/m3(最大值,昼夜均值)
中国(待颁布) 饮用水源中有害物质的最高容许浓度 0.05mg/L
中国(GHZB1-1999) 地表水环境质量标准(I、II、III类水域) 0.05mg/L


6.应急处理处置方法:


一、泄漏应急处理

隔离泄漏污染区,周围设警告标志,切断火源。应急处理人员戴好防毒面具,穿一般消防防护服。用洁净的铲子收集于干燥洁净有盖的容器中,用水泥、沥青或适当的热塑性材料固化处理再废弃。如大量泄漏,收集回收或无害处理后废弃。
废弃物处置方法:目前处置方法包括焚烧法、深井灌注法和填埋法。最有效的方法是焚烧法。
二、防护措施

呼吸系统防护:可能接触其粉尘时,应该佩戴防毒口罩。紧急事态抢救或撤离时,建议佩戴自给式呼吸器。
眼睛防护:必要时戴化学安全防护眼镜。
防护服:穿工作服。
手防护:戴防化学品手套。
其它:工作现场禁止吸烟、进食和饮水。工作后,彻底清洗。及时换洗工作服。注意个人清洁卫生。
三、急救措施

皮肤接触:脱去污染的衣着,用大量清水彻底冲洗。
眼睛接触:立即翻开上下眼睑,用流动清水或生理盐水冲洗。就医。
吸入:迅速脱离现场至空气新鲜处。保持呼吸道通畅。呼吸困难时给输氧。呼吸停止时,立即进行人工呼吸。就医。
食入:给饮足量温水,催吐。就医。

灭火方法:雾状水、泡沫、二氧化碳、干粉、砂土。

毒理学数据:

1.急性毒性

LD50:3500mg/kg(大鼠经口);4000mg/kg(小鼠经口);2600mg/kg(兔经口)

2.刺激性 暂无资料

3.亚急性与慢性毒性 动物亚急性和慢性毒性反应有神经毒性症状,肝、肾重量增加,尿中粪卟啉排泄增加等。

4.致突变性 DNA损伤:鼠伤寒沙门菌20μmol/L。微生物致突变:酿酒酵母菌100ppm。DNA加合物:大肠杆菌20μmol/L。哺乳动物体细胞突变:仓鼠肺6mg/L。

5.致畸性 大鼠孕后10~13d经口给予最低中毒剂量(TDLo)40mg/kg,致肌肉骨骼系统发育畸形。大鼠孕后1~22d经口给予最低中毒剂量(TDLo)6450mg/kg,致血液和淋巴系统(包括脾和骨髓)、免疫和网状内皮系统发育畸形。小鼠孕后7~16d经口给予最低中毒剂量(TDLo)1g/kg,颅面部(包括鼻、舌)、泌尿系统发育畸形。雌鼠交配前14d经口给予最低中毒剂量(TDLo)100mg/kg,致中枢神经系统发育畸形。

6.致癌性 IARC致癌性评论:G2B,可疑人类致癌物。

7.其他大鼠经口最低中毒剂量(TDLo):40mg/kg(孕后10~13d用药),对胎鼠肌肉、骨骼系统有影响。小鼠经口最低中毒剂量(TDLo):1g/kg,有胚胎毒性,对泌尿生殖系统有影响。

生态学数据:

1.生态毒性

LC50:22mg/L(96h)(黑头呆鱼,静态);12mg/L(96h)(蓝鳃太阳鱼,静态)

2.生物降解性

好氧生物降解(h):23256~50136

厌氧生物降解(h):93024~200544

3.非生物降解性

光解最大光吸收波长范围(nm):291~301

空气中光氧化半衰期(h):3753~37530

4.生物富集性 BCF:11000~27000(鲤鱼,接触浓度0.5ppb,接触时间8周);6000~30000(鲤鱼,接触浓度0.05ppb,接触时间8周)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA2975000
CHEMICAL NAME :
Benzene, hexachloro-
CAS REGISTRY NUMBER :
118-74-1
BEILSTEIN REFERENCE NO. :
1912585
LAST UPDATED :
199712
DATA ITEMS CITED :
68
MOLECULAR FORMULA :
C6-Cl6
MOLECULAR WEIGHT :
284.76
WISWESSER LINE NOTATION :
GR BG CG DG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3600 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1600 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1800 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
>6400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2022 mg/kg/55D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1596 mg/kg/28D-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3326 mg/kg/15W-I
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg/6W-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1729 mg/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Endocrine - adrenal cortex hyperplasia Blood - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg/5W-I
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg/60D-C
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1512 mg/kg/18W-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
842 mg/kg/6W-C
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
36400 mg/kg/1Y-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
3840 mg/kg/60D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
455 mg/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in thyroid weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
4704 mg/kg/28W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Endocrine - changes in thyroid weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
5 gm/kg/10D-I
TOXIC EFFECTS :
Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
2500 mg/kg/5D-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2738 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Blood - leukemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6972 mg/kg/83W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
1000 mg/kg/18W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - thyroid tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
3360 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
3360 mg/kg/80W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5475 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1050 mg/kg/30W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6300 mg/kg/90W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
556 mg/kg
SEX/DURATION :
female 96 day(s) pre-mating - 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
40 mg/kg
SEX/DURATION :
female 10-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6450 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
88 mg/kg
SEX/DURATION :
male 70 day(s) pre-mating female 70 day(s) pre-mating - 22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
812 mg/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
212 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating - 17 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 gm/kg
SEX/DURATION :
female 7-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
625 mg/kg
SEX/DURATION :
female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
910 ug/kg
SEX/DURATION :
female 13 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
27562 ug/kg
SEX/DURATION :
female 66 day(s) pre-mating - 28 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
6 mg/L
REFERENCE :
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 39,359,1986 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.002 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,155,1979 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,219,1987 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,219,1987 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 56,107,1975 TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 183,88,1963 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-RUSSIA:STEL 0.9 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1753 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 12 No. of Employees: 1038 (estimated) No. of Female Employees: 26 (estimated)

符号 GHS02 GHS07 GHS08 GHS09
GHS02, GHS07, GHS08, GHS09
信号词 Danger
危害声明 H225-H319-H336-H350-H411
补充危害声明 Repeated exposure may cause skin dryness or cracking.
警示性声明 P201-P210-P273-P280-P304 + P340 + P312-P308 + P313
个人防护装备 dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲) T:Toxic;N:Dangerousfortheenvironment;
风险声明 (欧洲) R45;R48/25;R50/53
安全声明 (欧洲) S53-S45-S60-S61-S62-S36/37-S33-S29-S16-S9-S26
危险品运输编码 UN 2729 6.1/PG 3
WGK德国 3
RTECS号 DA2975000
包装等级 III
危险类别 6.1(b)
海关编码 2903920000

1.三氯苯氯法将三氯苯加热至110℃,保温干燥1h,能氯气氯化,反应时放出热量,起始温度100-120℃,最终温度为260-270℃,氯化10-14h,当温度开始下降时即表示氯化反应已达终点,停止通氯,将熔融的物料放入盛水的结晶箱,搅拌下六氯苯结晶成粒。用冷水洗涤,即得六氯苯。

2.六六六无效体直接氯化法无效体经热风干燥至含水量在1%以下,加入熔融釜中,加热至150-170℃熔化,然后加入洗涤器和氯化塔。洗涤器温度保持在210-230℃,氯化塔通氯后,依照反应热慢慢升温,控制通氯速度,使反应温度每小时上升2-3℃。氯化塔的含氯尾气通入洗涤器吸收后送至副产盐酸系统。当氯化温度达260-270℃,并迅速放入盛水的结晶罐中骤冷结晶即得成品。

海关编码 2903920000
中文概述 2903920000 六氯苯(ISO)及滴滴涕(ISO,INN)〔六氯苯别名过氯苯,滴滴涕别名[1,1,1-三氯-2,2-双(4-氯苯基)乙烷]〕。监管条件:89(禁止出口商品,禁止进口商品)。增值税率:17.0%。退税率:0.0%。最低关税:5.5%。普通关税:30.0%
申报要素 品名, 成分含量, 用途
监管条件 8.禁止出口商品 9.禁止进口商品
Summary 2903920000 perchlorobenzene。supervision conditions:89(articles on the list of prohibited export goods,articles on the list of prohibited import goods)。VAT:17.0%。tax rebate rate:0.0%。MFN tarrif:5.5%。general tariff:30.0%