91374-20-8

• 常用中文名：盐酸罗匹尼罗
• 常用英文名：Ropinirole hydrochloride
• CAS号：91374-20-8
• 分子式：C₁₆H₂₅ClN₂O
• 分子量：296.836
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) Dopamine Receptor 激动剂
• 发布时间：2019-01-19 19:56:31
• 更新时间：2024-01-02 11:41:09
• Ropinirole(SKF101468)盐酸盐是多巴胺受体D2抑制剂，IC50为29 nM。

名称

• 中文名: 4-(2-二正丙基胺乙基)-1,3-二氯-2H-吲哚-2-酮
• 英文名: 4-(2-(Dipropylamino)ethyl)indolin-2-one hydrochloride
• 中文别名: 4-[2-二正丙基胺乙基]-1,3-二氢-2H-吲哚-2-酮盐酸盐; 盐酸罗匹尼罗; 盐酸罗匹尼罗
• 英文别名: 2H-Indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-, hydrochloride (1:1); 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride; 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride (1:1); 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-onhydrochlorid; UNII-D7ZD41RZI9; ropinirole hcl; 4-[2-(dipropylamino)éthyl]-1,3-dihydro-2H-indol-2-one chlorhydrate; Adartrel; MFCD01754173; Ropinirole hydrochloride; 2H-indol-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-, monohydrochloride; Requip; Ropinirole (hydrochloride)

物化性质

• 沸点: 410.5ºC at 760mmHg
• 熔点: 241-243ºC
• 分子式: C₁₆H₂₅ClN₂O
• 分子量: 296.836
• 精确质量: 296.165527
• PSA: 32.34000
• LogP: 3.78570
• 外观性状: 灰白色固体
• 储存条件: Room temp

生物活性

• 描述: Ropinirole(SKF101468)盐酸盐是多巴胺受体D2抑制剂,IC50为29 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54.

  [2]. Iida, M., et al., Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res, 1999. 838(1-2): p. 51-9.

  [3]. Lam, Y.W., Clinical pharmacology of dopamine agonists. Pharmacotherapy, 2000. 20(1 Pt 2): p. 17S-25S.

  [4]. Allen, R., et al., Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome. Sleep, 2004. 27(5): p. 907-14.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NM3288250 CHEMICAL NAME : 2H-Indol-2-one, 1,3-dihydro-4-(2-(dipropylamino)ethyl)-, monohydrochloride CAS REGISTRY NUMBER : 91374-20-8 LAST UPDATED : 199807 DATA ITEMS CITED : 9 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 396 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1725,199 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 71 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1725,199 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 mg/kg/30D-I TOXIC EFFECTS : Liver - changes in liver weight Endocrine - changes in adrenal weight Related to Chronic Data - changes in ovarian weight REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1731,199 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18250 mg/kg/1Y-I TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - other changes Endocrine - changes in adrenal weight REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1731,199 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 450 mg/kg/30D-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - excitement Skin and Appendages - hair REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1741,199 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 5475 mg/kg/1Y-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in testicular weight REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1741,199 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3040 mg/kg SEX/DURATION : female 2 week(s) pre-mating - 20 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1747,199 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1 gm/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1747,199 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 280 mg/kg SEX/DURATION : female 15-21 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 24(Suppl 11),S1747,199

安全

• 符号: GHS07, GHS09
• 信号词: Warning
• 危害声明: H302-H400
• 警示性声明: P301 + P312 + P330
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn,N
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): 36-60-61-37/39-26
• 危险品运输编码: UN 3077 9/PG 3
• RTECS号: NM3288250
• 危险类别: 9.0
• 海关编码: 2933790090

合成路线

91374-25-3 ~89% 91374-20-8

文献：IND-SWIFT LABORATORIES LIMITED Patent: WO2008/84499 A1, 2008 ; Location in patent: Page/Page column 8 ;

142-84-7 120427-96-5 ~50% 91374-20-8

文献：TORRENT PHARMACEUTICALS LTD Patent: WO2005/80333 A1, 2005 ; Location in patent: Page/Page column 23 ;

142-84-7 120427-95-4 ~% 91374-20-8

文献：WO2011/30330 A2, ; Page/Page column 9 ;

91374-21-9 ~% 91374-20-8

文献：WO2005/40115 A1, ; Page/Page column 6 ;

863436-07-1 ~40% 91374-20-8

文献：Helm AG; CF Pharma Gyogyszergyarto Kft. Patent: EP1568689 A1, 2005 ; Location in patent: Page/Page column 7 ;

142-84-7 139122-20-6 ~85% 91374-20-8

文献：Hayler, John D.; Howie, Simon L. B.; Giles, Robert G.; Negus, Alan; Oxley, Paul W.; Walsgrove, Timothy C.; Whiter Organic Process Research and Development, 1998 , vol. 2, # 1 p. 3 - 9

920986-68-1 ~% 91374-20-8

文献：WO2011/72704 A1, ;

139122-17-1 ~% 91374-20-8

文献：Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9

139122-18-2 ~% 91374-20-8

文献：Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9

上下游产品

上游产品  10
91374-25-3 142-84-7 120427-96-5 120427-95-4
91374-21-9 863436-07-1 139122-20-6 920986-68-1
139122-17-1 139122-18-2
下游产品  1
91374-21-9

海关

海关编码	2933790090
中文概述	2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:9.0% 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%