Development of Large-Scale Syntheses of Ropinirole in the Pursuit of a Manufacturing Process1

JD Hayler, SLB Howie, RG Giles, A Negus…

文献索引：Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9

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被引用次数: 9

摘要

... Organic Process Research & Development. ... was performed under more dilute conditions (100−1000-fold), hence casting doubt on a bimolecular process. ... iminium salt intermediate 25 is suppressed, hence promoting alternative hydride transfer and hydrolysis processes to give ...